Journal article
Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective
Critical reviews in food science and nutrition, Vol.57(18), pp.3830-3839
12/12/2017
Handle:
https://hdl.handle.net/2376/116560
PMID: 27008212
Abstract
Impairment of the epithelial barrier function is closely linked to the pathogenesis of various gastrointestinal diseases, food allergies, type I diabetes, and other systematic diseases. Plant-derived polyphenols are natural secondary metabolites and exert various physiological benefits, including anti-inflammatory, anti-oxidative, anti-carcinogenic, and anti-aging effects. Recent studies also show the role of plant polyphenols in regulation of the intestinal barrier and prevention of intestinal inflammatory diseases. Here we summarize the regulatory pathways and mediators linking polyphenols to their beneficial effects on tight junction and gut epithelial barrier functions, and provide useful information about using polyphenols as nutraceuticals for intestinal diseases.
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Details
- Title
- Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective
- Creators
- Guan Yang - School of Food Science, Washington State UniversityShima Bibi - School of Food Science, Washington State UniversityMin Du - Department of Animal Science, Washington State UniversityTakuya Suzuki - Department of Biofunctional Science and Technology, Hiroshima UniversityMei-Jun Zhu - School of Food Science, Washington State University
- Publication Details
- Critical reviews in food science and nutrition, Vol.57(18), pp.3830-3839
- Academic Unit
- Animal Sciences, Department of; Food Science, School of
- Publisher
- Taylor & Francis
- Identifiers
- 99900548492701842
- Language
- English
- Resource Type
- Journal article