- Title
- Replication of Lung Cancer Susceptibility Loci at Chromosomes 15q25, 5p15, and 6p21: A Pooled Analysis From the International Lung Cancer Consortium
- Creators
- Therese Truong - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramRayjean J Hung - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramChristopher I Amos - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramXifeng Wu - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramHeike Bickeböller - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramAlbert Rosenberger - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramWiebke Sauter - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramThomas Illig - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramH.-Erich Wichmann - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramAngela Risch - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramHendrik Dienemann - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramRudolph Kaaks - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramPing Yang - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramRuoxiang Jiang - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramJohn K Wiencke - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramMargaret Wrensch - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramHelen Hansen - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramKarl T Kelsey - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramKeitaro Matsuo - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramKazuo Tajima - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramAnn G Schwartz - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramAngie Wenzlaff - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramAdeline Seow - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramChen Ying - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramAndrea Staratschek-Jox - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramPeter Nürnberg - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramErich Stoelben - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramJürgen Wolf - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramPhilip Lazarus - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramJoshua E Muscat - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramCarla J Gallagher - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramShanbeh Zienolddiny - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramAage Haugen - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramHenricus F. M van der Heijden - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramLambertus A Kiemeney - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramDolores Isla - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramJose Ignacio Mayordomo - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramThorunn Rafnar - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramKari Stefansson - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramZuo-Feng Zhang - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramShen-Chih Chang - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramJin Hee Kim - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramYun-Chul Hong - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramEric J Duell - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramAngeline S Andrew - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramFlavio Lejbkowicz - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramGad Rennert - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramHeiko Müller - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramHermann Brenner - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramLoïc Le Marchand - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramSimone Benhamou - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramChristine Bouchardy - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramM. Dawn Teare - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramXiaoyan Xue - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramJohn McLaughlin - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramGeoffrey Liu - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramJames D McKay - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramPaul Brennan - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research ProgramMargaret R Spitz - Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (TT, JDM, PB); Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, INSERM, U1018, Villejuif, France (TT); Samuel Lunenfeld Research Institute, Toronto, ON, Canada (RJH); Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, TX (CIA, XW, MS); Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany (HBi, ARo); Institute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (WS, H-EW); Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany (TI); Division of Epigenomics and Cancer Risk Factors (ARi) and Division of Clinical Epidemiology and Aging Research (HM, HBr), German Cancer Research Center (DKFZ), Heidelberg, Germany; Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany (HD); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (RK); Department of Health Sciences Research, Mayo Clinic Cancer Center, Rochester, MN (PY, RJ); Departments of Neurological Surgery and Epidemiology and Biostatistics, University of California, San Francisco, CA (JKW, MW, HH); Departments of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, RI (KTK); Aichi Cancer Center Research Institute, Nagoya, Japan (KM, KT); Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI (AGS, AW); Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore (AS, CY); LIMES (Life and Medical Sciences Bonn), Genomics and Immunoregulation, University of Bonn, Bonn, Germany (AS-J); Cologne Center for Genomics and the Institute for Genetics, University of Cologne, Cologne, Germany (PN); Lung Clinic, Hospital of Cologne, Cologne, Germany (ES); Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany (JW); Penn State College of Medicine, Hershey, PA (PL, JEM, CG, Y-CH); Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway (SZ, AH); Department of Pulmonary Diseases (HFMvdH) and Department of Epidemiology, Biostatistics and HTA (LAK), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands; Division of Medical Oncology, University Hospital, Zaragoza, Spain (DI); Division of Medical Oncology, University Hospital, University of Zaragoza, and Health Sciences Institute, Nanotechnology Institute of Aragon, Zaragoza, Spain (JIM); deCODE Genetics, Reykjavik, Iceland (TR, KS); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (KS); Department of Epidemiology, University of California Los Angeles, Los Angeles, CA (Z-FZ, S-CC); Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (JHK, Y-CH); Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea (JHK, Y-CH); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program
- Publication Details
- JNCI : Journal of the National Cancer Institute, Vol.102(13), pp.959-971
- Academic Unit
- Pharmaceutical Sciences, Department of
- Publisher
- Oxford University Press
- Identifiers
- 99900547301001842
- Language
- English
- Resource Type
- Journal article
Journal article
Replication of Lung Cancer Susceptibility Loci at Chromosomes 15q25, 5p15, and 6p21: A Pooled Analysis From the International Lung Cancer Consortium
JNCI : Journal of the National Cancer Institute, Vol.102(13), pp.959-971
07/07/2010
Handle:
https://hdl.handle.net/2376/108652
PMCID: PMC2897877
PMID: 20548021
Metrics
7 Record Views