Journal article
Reproductive and neurological Quakingviable phenotypes in a severe combined immune deficient mouse background
Immunogenetics (New York), Vol.57(3-4), pp.226-231
05/2005
Handle:
https://hdl.handle.net/2376/109248
PMCID: PMC2604809
PMID: 15900494
Abstract
The
quaking
viable
(
qk
v
) mutation, a spontaneous deletion of a multigenic region encompassing roughly 1 Mb at 5.9 cM on the proximal end of mouse chromosome 17, causes severe trembling in all homozygous animals and infertility in all homozygous males. Physiologically, quaking mice exhibit dysmyelination and postmeiotic spermatogenic arrest. Molecular defects in
Qk
v
mice occur in the affected tissues, indicating the primary causes of these pathologies are cell autonomous. However, because both the reproductive and neurological defects are in immune-privileged sites and because some similar pathologies at both sites have been shown to be immune mediated, we tested whether the immune system participates secondarily in manifestation of
Qk
v
phenotypes. The
qk
v
mutation was bred into a severe combined immune-deficient mouse line (SCID; devoid of mature B and T cells) and penetrance of the neurological and the male sterile phenotypes was measured. Results showed that neither defect was ameliorated in the immune-deficient background. We conclude that the
Qk
v
pathologies do not likely involve a B- or T-cell-dependent response against these immune-privileged sites.
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Details
- Title
- Reproductive and neurological Quakingviable phenotypes in a severe combined immune deficient mouse background
- Creators
- Tammy A Tucker - Veterinary Molecular Biology, Montana State University, Molecular Biosciences Building, 960 Technology Boulevard, Bozeman, MT, 59718, USAJean A Kundert - Animal Resource Center, Montana State University, Bozeman, MT, 59717, USAAlla A Bondareva - Veterinary Molecular Biology, Montana State University, Molecular Biosciences Building, 960 Technology Boulevard, Bozeman, MT, 59718, USAEdward E Schmidt - Veterinary Molecular Biology, Montana State University, Molecular Biosciences Building, 960 Technology Boulevard, Bozeman, MT, 59718, USA
- Publication Details
- Immunogenetics (New York), Vol.57(3-4), pp.226-231
- Academic Unit
- UNKNOWN
- Identifiers
- 99900547040801842
- Language
- English
- Resource Type
- Journal article