Journal article
Resilience and vulnerability: a neurobiological perspective
F1000 prime reports, Vol.5, pp.13-13
2013
Handle:
https://hdl.handle.net/2376/103543
PMCID: PMC3643078
PMID: 23710327
Abstract
The brain is constantly adapting to a changing environment. It detects environmental stimuli, integrates that information with internal states, and engages appropriate behavioral and physiological responses. This process of stability through change is termed "allostasis", and serves as a mechanism by which an organism can adapt to a changing environment to function optimally, and ultimately ensure survival. The ability to adapt to stressors in the environment by "bending" but not "breaking" can be considered as "resilience". Individuals that are more able to withstand such challenges to their stability, and bounce back after, can be considered more resilient than those that do not. This review will explore what resilience means in a neurobiological context, the role of stress and allostasis, and focuses on the role of neurotrophins, particularly BDNF, in mediating adaptive plasticity.
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Details
- Title
- Resilience and vulnerability: a neurobiological perspective
- Creators
- Ilia N Karatsoreos - Department of Integrative Physiology and Neuroscience, Washington State University, Veterinary and Biomedical Research Building 1815 Ferdinand's Lane, Pullman, WA, 99163Bruce S McEwen
- Publication Details
- F1000 prime reports, Vol.5, pp.13-13
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- England
- Grant note
- R01 MH041256 / NIMH NIH HHS
- Identifiers
- 99900546530501842
- Language
- English
- Resource Type
- Journal article