Response of Sod-2 enzyme activity to selection for high voluntary wheel running

S L Thomson; T Garland, Jr; J G Swallow; P A Carter

doi:10.1038/sj.hdy.6800008

Back

Response of Sod-2 enzyme activity to selection for high voluntary wheel running

Journal article

Open access

Peer reviewed

Response of Sod-2 enzyme activity to selection for high voluntary wheel running

S L Thomson, T Garland, Jr, J G Swallow and P A Carter

Heredity, Vol.88(1), pp.52-61

01/2002

DOI: https://doi.org/10.1038/sj.hdy.6800008

Handle:

https://hdl.handle.net/2376/109434

PMID: 11813107

Files and links (1)

url

https://doi.org/10.1038/sj.hdy.6800008View

Published (Version of record) Open

Abstract

Locomotion

Animals

Analysis of Variance

Oxidative Stress

Breeding

Selection, Genetic

Female

Male

Mice

Physical Exertion

Superoxide Dismutase - metabolism

The objective of this study was to examine the correlated response of anti-oxidant enzyme activity to selective breeding for increased voluntary wheel running in house mice. Activity of liver superoxide dismutase-2 (Sod-2), a free radical scavenger, was measured in four groups of mice. 'Active' individuals were housed in cages with attached wheels for 8 weeks beginning at weaning; 'sedentary' individuals were housed in cages with attached wheels that were prevented from rotating. Both of these treatments were applied to male and female mice from generation 14 of a replicated artificial selection experiment, which is composed of four lines selected for high wheel running and four randomly bred lines that serve as controls. In females, Sod-2 activity was significantly lower in selected vs control animals, regardless of presence/absence of a free-turning wheel. This difference suggests a trade-off between early-age voluntary wheel-running activity and Sod-2 activity. In males, Sod-2 activity was significantly affected by an interaction between selection group and activity group, with males from selected lines having lower Sod-2 activity relative to control males only in the sedentary treatment. These negative correlated responses of Sod-2 activity to selection on wheel running are discussed in the context of antagonistic pleiotropy models of aging and with respect to potential effects on lifespan.

Metrics

12 Record Views

Details

Title: Response of Sod-2 enzyme activity to selection for high voluntary wheel running
Creators: S L Thomson - School of Biological Sciences, Washington State University, Pullman, WA 99164, USA
T Garland, Jr
J G Swallow
P A Carter
Publication Details: Heredity, Vol.88(1), pp.52-61
Academic Unit: Biological Sciences, School of
Publisher: England
Identifiers: 99900547386701842
Language: English
Resource Type: Journal article