Risk factors for hospitalized seasonal influenza in rural western Kenya

Maurice O Ope; Mark A Katz; Barrack Aura; Stella Gikunju; M Kariuki Njenga; Zipporah Ng'ang'a; John Vulule; Robert F Breiman; Daniel R Feikin

doi:10.1371/journal.pone.0020111

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Risk factors for hospitalized seasonal influenza in rural western Kenya

Journal article

Open access

Risk factors for hospitalized seasonal influenza in rural western Kenya

Maurice O Ope, Mark A Katz, Barrack Aura, Stella Gikunju, M Kariuki Njenga, Zipporah Ng'ang'a, John Vulule, Robert F Breiman and Daniel R Feikin

PloS one, Vol.6(5), pp.e20111-e20111

2011

DOI: https://doi.org/10.1371/journal.pone.0020111

Handle:

https://hdl.handle.net/2376/103903

PMCID: PMC3102693

PMID: 21637856

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Abstract

Multivariate Analysis

Rural Population - statistics & numerical data

Demography

Kenya - epidemiology

Humans

Middle Aged

Risk Factors

Hospitalization - statistics & numerical data

Influenza, Human - epidemiology

Male

Influenza, Human - complications

Young Adult

Adolescent

HIV Infections - complications

Adult

Female

HIV Infections - drug therapy

Aged

Seasons

Child

Risk factors for influenza hospitalization in Africa are unknown, including the role of HIV. We conducted a case-control study of risk factors for hospitalized seasonal influenza among persons in rural western Kenya, a high HIV prevalence area, from March 2006-August 2008. Eligible cases were ≥five years old, admitted to health facilities with respiratory symptoms, and had nasopharyngeal/oropharyngeal swab specimens that tested positive for influenza A or B by real-time reverse transcription-PCR. Three randomly selected age-, sex- and neighborhood-matched controls were enrolled per case. A structured questionnaire was administered and home-based HIV testing was performed. Risk factors were evaluated using conditional logistic regression. A total of 64 cases (38 with influenza A and 26 with influenza B) and 190 controls were enrolled. The median age was 16 years (range 5-69 years). Among cases, 24.5% were HIV-infected versus 12.5% of controls (p = 0.004). Among persons ≥18 years old, 13 (59%) of 22 tested cases were HIV-positive compared with 15 (24%) of 62 tested controls (p = 0.005). In multivariable analysis, HIV-infection was associated with hospitalization due to influenza [adjusted Odds Ratio (aOR) 3.56, 95% CI 1.25-10.1]. The mean CD4 count among HIV-infected cases and controls was similar (399 vs. 387, respectively, p = 0.89). Chronic lung disease (aOR 6.83, 95% CI 1.37-34.0) was also associated with influenza hospitalization in multivariable analysis. Active pulmonary tuberculosis was associated with influenza hospitalization in bivariate, but not multivariable, analysis. People with HIV infection and chronic lung disease were at increased risk of hospitalized influenza in rural Kenya. HIV infection is common in many parts of sub-Saharan Africa. Influenza vaccine might prevent severe influenza in these risk groups.

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Title: Risk factors for hospitalized seasonal influenza in rural western Kenya
Creators: Maurice O Ope - Department of Disease Surveillance and Response, Ministry of Public Health and Sanitation, Nairobi, Kenya
Mark A Katz
Barrack Aura
Stella Gikunju
M Kariuki Njenga
Zipporah Ng'ang'a
John Vulule
Robert F Breiman
Daniel R Feikin
Publication Details: PloS one, Vol.6(5), pp.e20111-e20111
Academic Unit: Paul G. Allen School for Global Animal Health
Publisher: United States
Identifiers: 99900546952401842
Language: English
Resource Type: Journal article