Journal article
Ritonavir has minimal impact on the pharmacokinetic disposition of a single dose of bupropion administered to human volunteers
Journal of clinical pharmacology, Vol.46(5), pp.567-576
05/2006
Handle:
https://hdl.handle.net/2376/113571
PMID: 16638740
Abstract
A drug-drug interaction study was conducted to determine whether ritonavir (200 mg; 4 doses over 2 days) alters the pharmacokinetic disposition of bupropion (75 mg; once) coadministered to 7 healthy volunteers in a placebo-controlled 2-way crossover study. Serum samples collected from 0 to 24 hours after bupropion administration were assayed for concentrations of bupropion and metabolites (hydroxybupropion, threohydrobupropion, and erythrohydrobupropion). Derived pharmacokinetic parameters were compared between placebo/bupropion and ritonavir/bupropion trials by paired t test. The effect of ritonavir on most pharmacokinetic parameters was minimal (<20% mean change). The only parameters that showed a statistically significant effect were threohydrobupropion area under the blood concentration curve (14% +/- 5% decrease, mean +/- SE; P = .04) and erythrohydrobupropion time-to-maximal serum concentration (161% +/- 92% increase, P = .03), suggesting that ritonavir may inhibit the carbonyl reductase enzyme responsible for formation of these metabolites. These findings indicate that short-term ritonavir dosing has only minimal impact on the pharmacokinetic disposition of a single dose of bupropion in healthy volunteers.
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Details
- Title
- Ritonavir has minimal impact on the pharmacokinetic disposition of a single dose of bupropion administered to human volunteers
- Creators
- Leah M Hesse - Molecular Pharmacogenetics Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USADavid J GreenblattLisa L von MoltkeMichael H Court
- Publication Details
- Journal of clinical pharmacology, Vol.46(5), pp.567-576
- Academic Unit
- Veterinary Clinical Sciences, Department of
- Publisher
- England
- Grant note
- DK-58496 / NIDDK NIH HHS GM-61834 / NIGMS NIH HHS DA-05258 / NIDA NIH HHS AG-17880 / NIA NIH HHS AT-01381 / NCCIH NIH HHS GM-74369 / NIGMS NIH HHS DA-13209 / NIDA NIH HHS MH-58435 / NIMH NIH HHS
- Identifiers
- 99900548075101842
- Language
- English
- Resource Type
- Journal article