Journal article
Role of Bibersteinia trehalosi, respiratory syncytial virus, and parainfluenza-3 virus in bighorn sheep pneumonia
Veterinary microbiology, Vol.162(1), pp.166-172
02/22/2013
Handle:
https://hdl.handle.net/2376/107131
PMID: 23025980
Abstract
Pneumonic bighorn sheep (BHS) have been found to be culture- and/or sero-positive for Bibersteinia trehalosi, respiratory syncytial virus (RSV), and parainfluenza-3 virus (PI-3). The objective of this study was to determine whether these pathogens can cause fatal pneumonia in BHS. In the first study, two groups of four BHS each were intra-tracheally administered with leukotoxin-positive (Group I) or leukotoxin-negative (Group II) B. trehalosi. All four animals in Group I developed severe pneumonia, and two of them died within 3 days. The other two animals showed severe pneumonic lesions on euthanasia and necropsy. Animals in Group II neither died nor showed gross pneumonic lesions on necropsy, suggesting that leukotoxin-positive, but not leukotoxin-negative, B. trehalosi can cause fatal pneumonia in BHS.
In the second study, two other groups of four BHS (Groups III and IV) were intra-nasally administered with a mixture of RSV and PI-3. Four days later, RSV/PI-3-inoculated Group IV and another group of four BHS (Group V, positive control) were intra-nasally administered with Mannheimia haemolytica, the pathogen that consistently causes fatal pneumonia in BHS. All four animals in group III developed pneumonia, but did not die during the study period. However all four animals in Group IV, and three animals in Group V developed severe pneumonia and died within two days of M. haemolytica inoculation. The fourth animal in Group V showed severe pneumonic lesions on euthanasia and necropsy. These findings suggest that RSV/PI-3 can cause non-fatal pneumonia, but are not necessary predisposing agents for M. haemolytica-caused pneumonia of BHS.
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Details
- Title
- Role of Bibersteinia trehalosi, respiratory syncytial virus, and parainfluenza-3 virus in bighorn sheep pneumonia
- Creators
- Rohana P Dassanayake - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USASudarvili Shanthalingam - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USARenuka Subramaniam - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USACaroline N Herndon - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USAJegarubee Bavananthasivam - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USAGary J Haldorson - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USAWilliam J Foreyt - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USAJames F Evermann - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USALynn M Herrmann-Hoesing - Animal Disease Research Unit, USDA Agricultural Research Service, Washington State University, Pullman WA 99164-6630, USADonald P Knowles - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USASubramaniam Srikumaran - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USA
- Publication Details
- Veterinary microbiology, Vol.162(1), pp.166-172
- Academic Unit
- Veterinary Clinical Sciences, Department of; Veterinary Microbiology and Pathology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900546862101842
- Language
- English
- Resource Type
- Journal article