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CC BY-NC V4.0, Open Access
Journal article
Role of epigenetic transgenerational inheritance in generational toxicology
Environmental epigenetics, Vol.8(1), pp.dvac001-dvac001
02/16/2022
PMCID: PMC8848501
PMID: 35186326
Abstract
Many environmental toxicants have been shown to be associated with the transgenerational inheritance of increased disease susceptibility. This review describes the generational toxicity of some of these chemicals and their role in the induction of epigenetic transgenerational inheritance of disease. Epigenetic factors include DNA methylation, histone modifications, retention of histones in sperm, changes to chromatin structure, and expression of non-coding RNAs. For toxicant-induced epigenetic transgenerational inheritance to occur, exposure to a toxicant must result in epigenetic changes to germ cells (sperm or eggs) since it is the germ cells that carry molecular information to subsequent generations. In addition, the epigenetic changes induced in transgenerational generation animals must cause alterations in gene expression in these animals' somatic cells. In some cases of generational toxicology, negligible changes are seen in the directly exposed generations, but increased disease rates are seen in transgenerational descendants. Governmental policies regulating toxicant exposure should take generational effects into account. A new approach that takes into consideration generational toxicity will be needed to protect our future populations.
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Details
- Title
- Role of epigenetic transgenerational inheritance in generational toxicology
- Creators
- Eric E Nilsson - Washington State UniversityMillissia Ben Maamar - Washington State UniversityMichael K Skinner - Washington State University
- Publication Details
- Environmental epigenetics, Vol.8(1), pp.dvac001-dvac001
- Academic Unit
- Biological Sciences, School of
- Identifiers
- 99901080304101842
- Language
- English
- Resource Type
- Journal article