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CC BY V4.0, Open Access
Journal article
Roles of circadian clocks in cancer pathogenesis and treatment
Experimental & molecular medicine, Vol.53(10), pp.1529-1538
10/01/2021
PMID: 34615982
Abstract
Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h rhythms in cellular and bodily functions across nearly all living species. These internal clock systems enable living organisms to anticipate and respond to daily changes in their environment in a timely manner, optimizing temporal physiology and behaviors. Dysregulation of circadian rhythms by genetic and environmental risk factors increases susceptibility to multiple diseases, particularly cancers. A growing number of studies have revealed dynamic crosstalk between circadian clocks and cancer pathways, providing mechanistic insights into the therapeutic utility of circadian rhythms in cancer treatment. This review will discuss the roles of circadian rhythms in cancer pathogenesis, highlighting the recent advances in chronotherapeutic approaches for improved cancer treatment.
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Details
- Title
- Roles of circadian clocks in cancer pathogenesis and treatment
- Creators
- Yool Lee - Washington State University Spokane
- Publication Details
- Experimental & molecular medicine, Vol.53(10), pp.1529-1538
- Academic Unit
- Elson S. Floyd College of Medicine
- Identifiers
- 99901130944101842
- Language
- English
- Resource Type
- Journal article