Journal article
S-Nitrosothiols as novel, reversible inhibitors of human rhinovirus 3C protease
Bioorganic & medicinal chemistry letters, Vol.10(18), pp.2097-2100
2000
Handle:
https://hdl.handle.net/2376/108577
PMID: 10999479
Abstract
Human rhinovirus (HRV) 3C protease was inactivated by a series of
S-nitrosothiols. These compounds exhibited different inhibitory activities in a time- and concentration-dependent manner with second-order rate constants (
k
inact/
K
I) ranging from 131 to 5360
M
−1
min
−1. The inactive enzyme could be re-activated by DTT, GSH and ascorbate, which indicated the inactivation mechanism was through an
S-transnitrosylation process.
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Details
- Title
- S-Nitrosothiols as novel, reversible inhibitors of human rhinovirus 3C protease
- Creators
- Ming Xian - Department of Chemistry, Wayne State University, Detroit, MI 48202, USAQ.May Wang - Infectious Diseases Research, Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USAXinchao Chen - Department of Chemistry, Wayne State University, Detroit, MI 48202, USAKun Wang - Department of Chemistry, Wayne State University, Detroit, MI 48202, USAPeng G Wang - Department of Chemistry, Wayne State University, Detroit, MI 48202, USA
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.10(18), pp.2097-2100
- Academic Unit
- Chemistry, Department of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900547317101842
- Language
- English
- Resource Type
- Journal article