Journal article
S-Persulfidation: Chemistry, Chemical Biology, and Significance in Health and Disease
Antioxidants & redox signaling, Vol.33(15), pp.1092-1114
11/20/2020
Handle:
https://hdl.handle.net/2376/107921
PMID: 31547682
Abstract
S-Persulfidation generates persulfide adducts (RSSH) on both small molecules and proteins. This process is believed to be critical in the regulation of biological functions of reactive sulfur species such as H
S, as well as in signal transduction. S-Persulfidation also plays regulatory roles in human health and diseases.
Some mechanisms underlying the generation of low-molecular-weight persulfides and protein S-persulfidation in living organisms have been uncovered. Some methods for the specific delivery of persulfides and the detection of persulfides in biological systems have been developed. These advances help to pave the road to better understand the functions of S-persulfidation.
Persulfides are highly reactive and unstable. Currently, their identification relies on trapping them by S-alkylation, but this is not always reliable due to rapid sulfur exchange reactions. Therefore, the presence, identity, and fates of persulfides in biological environments are sometimes difficult to track.
Further understanding the fundamental chemistry/biochemistry of persulfides and development of more reliable detection methods are needed. S-Persulfidation in specific protein targets is essential in organismal physiological health and human disease states. Besides cardiovascular and neuronal systems, the roles of persulfidation in other systems need to be further explored. Contradictory results of persulfidation in biology, especially in cancer, need to be clarified.
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Details
- Title
- S-Persulfidation: Chemistry, Chemical Biology, and Significance in Health and Disease
- Creators
- Chun-Tao Yang - Department of Chemistry, Washington State University, Pullman, Washington, USANelmi O Devarie-Baez - Department of Chemistry, Washington State University-Tri Cities, Richland, Washington, USAAkil Hamsath - Department of Chemistry, Washington State University, Pullman, Washington, USAXiao-Dong Fu - Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Protein Modification and Degradation Key Lab of Guangzhou and Guangdong, Key Laboratory of Molecular Clinical Pharmacology in School of Pharmaceutics Science, Guangzhou Medical University, Guangzhou, ChinaMing Xian - Department of Chemistry, Washington State University, Pullman, Washington, USA
- Publication Details
- Antioxidants & redox signaling, Vol.33(15), pp.1092-1114
- Academic Unit
- Chemistry, Department of
- Publisher
- United States
- Grant note
- R21 DA046386 / NIDA NIH HHS R01 GM125968 / NIGMS NIH HHS
- Identifiers
- 99900546811501842
- Language
- English
- Resource Type
- Journal article