Journal article
SMC1β-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction
Nature genetics, Vol.37(12), pp.1351-1355
12/2005
Handle:
https://hdl.handle.net/2376/116846
PMID: 16258540
Abstract
Mitotic chromosome segregation is facilitated by the cohesin complex, which maintains physical connections between sister chromatids until anaphase. Meiotic cell division is considerably more complex, as cohesion must be released sequentially to facilitate orderly segregation of chromosomes at both meiosis I and meiosis II. This necessitates meiosis-specific cohesin components; recent studies in rodents suggest that these influence chromosome behavior during both cell division and meiotic prophase. To elucidate the role of the meiosis-specific cohesin SMC1β (encoded by Smc1l2) in oogenesis, we carried out meiotic studies of female SMC1β-deficient mice. Our results provide the first direct evidence that SMC1β acts as a chiasma binder in mammals, stabilizing sites of exchange until anaphase. Additionally, our observations support the hypothesis that deficient cohesion is an underlying cause of human age-related aneuploidy.
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Details
- Title
- SMC1β-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction
- Creators
- Ekaterina Revenkova - Department of Gene and Cell Medicine, Mount Sinai School of MedicineRolf Jessberger - Department of Gene and Cell Medicine, Mount Sinai School of Medicine Department of Physiological Chemistry, Dresden University of TechnologyCraig A Hodges - Department of Genetics, Case Western Reserve UniversityTerry J Hassold - Center for Reproductive Biology and School of Molecular Biosciences, Washington State UniversityPatricia A Hunt - Center for Reproductive Biology and School of Molecular Biosciences, Washington State University
- Publication Details
- Nature genetics, Vol.37(12), pp.1351-1355
- Academic Unit
- Molecular Biosciences, School of
- Identifiers
- 99900547772701842
- Language
- English
- Resource Type
- Journal article