Journal article
Selecting peptides to optimize Th1 responses to an equine lentivirus using HLA-DR binding motifs and defined HIV-1 Th peptides
Immunogenetics (New York), Vol.55(7), pp.508-514
10/2003
Handle:
https://hdl.handle.net/2376/114595
PMID: 12942208
Abstract
Three moderately to broadly recognized equine infectious anemia virus (EIAV) peptides that contained helper T-lymphocyte (Th) 1 epitopes were previously identified. Although lipopeptide immunization was only weakly immunostimulatory in a preliminary study, as measured by T-lymphocyte proliferation responses, it was of interest to define additional broadly recognized Th1 epitopes to include in future immunization trials. Using broadly cross-reactive and conserved Th epitopes known in the related human immunodeficiency virus-1 (HIV-1) and binding motifs defined in human leukocyte antigen DR molecules as guides, this work identified three new peptides containing Th1 epitopes recognized by 60–75% of EIAV infected horses. The observed similarity across species of major histocompatibility complex (MHC) class II binding motifs and the conservation of Th peptides between related viruses should allow easier targeting of Th epitope regions in less well characterized pathogens and/or in species whose MHC class II molecules are poorly defined.
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Details
- Title
- Selecting peptides to optimize Th1 responses to an equine lentivirus using HLA-DR binding motifs and defined HIV-1 Th peptides
- Creators
- Darrilyn Fraser - Department of Veterinary Microbiology and Pathology Washington State University Pullman WA 99164-7040 USARobert Mealey - Department of Veterinary Microbiology and Pathology Washington State University Pullman WA 99164-7040 USATravis McGuire - Department of Veterinary Microbiology and Pathology Washington State University Pullman WA 99164-7040 USA
- Publication Details
- Immunogenetics (New York), Vol.55(7), pp.508-514
- Academic Unit
- Veterinary Clinical Sciences, Department of
- Publisher
- Springer-Verlag; Berlin/Heidelberg
- Identifiers
- 99900547888101842
- Language
- English
- Resource Type
- Journal article