Journal article
Selection for Simple Major Surface Protein 2 Variants during Anaplasma marginale Transmission to Immunologically Naïve Animals
Infection and immunity, Vol.75(3), pp.1502-1506
03/2007
Handle:
https://hdl.handle.net/2376/101587
PMCID: PMC1828556
PMID: 17178787
Abstract
Anaplasma marginale
, a rickettsial pathogen, evades clearance in the animal host by antigenic variation. Under immune selection,
A. marginale
expresses complex major surface protein 2 mosaics, derived from multiple donor sequences. However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission.
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Details
- Title
- Selection for Simple Major Surface Protein 2 Variants during Anaplasma marginale Transmission to Immunologically Naïve Animals
- Creators
- Guy H Palmer - Program in Vector-borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State UniversityJames E Futse - Program in Vector-borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State UniversityChristina K Leverich - Program in Vector-borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State UniversityDonald P Knowles - Program in Vector-borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State UniversityFred R Rurangirwa - Program in Vector-borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State UniversityKelly A Brayton - Program in Vector-borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University
- Publication Details
- Infection and immunity, Vol.75(3), pp.1502-1506
- Academic Unit
- Veterinary Microbiology and Pathology, Department of; Paul G. Allen School for Global Animal Health
- Publisher
- American Society for Microbiology
- Identifiers
- 99900546641201842
- Language
- English
- Resource Type
- Journal article