Journal article
Sensitization of Olfactory Guanylyl Cyclase to a Specific Imprinted Odorant in Coho Salmon
Neuron (Cambridge, Mass.), Vol.19(2), pp.381-389
08/1997
Handle:
https://hdl.handle.net/2376/109074
PMID: 9292727
Abstract
The role of cGMP in olfactory signaling is not fully understood, but it is believed to play a modulatory role in intracellular signaling in vertebrate olfactory receptor neurons (ORNs). Here, we present evidence that cGMP in ORNs may play an important role in recognition of biologically relevant odors and olfactory learning. Specifically, we investigated the cellular mechanisms underlying olfactory imprinting in salmon. Salmon learn odors associated with their natal site as juveniles and later use these odors to guide their homing migration. This imprinting is believed to involve sensitization of the peripheral olfactory system to specific homestream odorants. We imprinted juvenile salmon to the odorant β-phenylethyl alcohol (PEA) and examined the sensitivity of olfactory adenylyl and guanylyl cyclases to PEA during development. Stimulation of guanylyl cyclase activity by PEA was significantly greater in olfactory cilia isolated from PEA- imprinted salmon compared with PEA-naive fish only at the time of the homing migration, 2 years after PEA exposure. These results suggest that sensitization of olfactory guanylyl cyclase may play an important role in olfactory imprinting by salmon.
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Details
- Title
- Sensitization of Olfactory Guanylyl Cyclase to a Specific Imprinted Odorant in Coho Salmon
- Creators
- Andrew H Dittman - Department of Pharmacology, Box 357280, USAThomas P Quinn - School of Fisheries, Box 357980, USAGabrielle A Nevitt - Department of Zoology, Box 351800, University of Washington, Seattle, Washington 98195, USABeth Hacker - Department of Pharmacology, Box 357280, USADaniel R Storm - Department of Pharmacology, Box 357280, USA
- Publication Details
- Neuron (Cambridge, Mass.), Vol.19(2), pp.381-389
- Academic Unit
- UNKNOWN
- Publisher
- Elsevier Inc
- Identifiers
- 99900547225401842
- Language
- English
- Resource Type
- Journal article