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Journal article
Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma
Research (Washington), Vol.2021, p.9861384
2021
PMID: 34104892
Abstract
Near-infrared (NIR) laser-induced phototherapy through NIR agents has demonstrated the great potential for cancer therapy. However, insufficient tumor killing due to the nonuniform heat or cytotoxic singlet oxygen (
1
O
2
) distribution over tumors from phototherapy results in tumor recurrence and inferior outcomes. To achieve high tumor killing efficacy, one of the solutions is to employ the combinational treatment of phototherapy with other modalities, especially with chemotherapeutic agents. In this paper, a simple and effective multimodal therapeutic system was designed
via
combining chemotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT) to achieve the polytherapy of malignant glioma which is one of the most aggressive tumors in the brain. IR-780 (IR780) dye-labeled tube-forming peptoids (PepIR) were synthesized and self-assembled into crystalline nanotubes (PepIR nanotubes). These PepIR nanotubes showed an excellent efficacy for PDT/PTT because the IR780 photosensitizers were effectively packed and separated from each other within crystalline nanotubes by tuning IR780 density; thus, a self-quenching of these IR780 molecules was significantly reduced. Moreover, the efficient DOX loading achieved due to the nanotube large surface area contributed to an efficient and synergistic chemotherapy against glioma cells. Given the unique properties of peptoids and peptoid nanotubes, we believe that the developed multimodal DOX-loaded PepIR nanotubes in this work offer great promises for future glioma therapy in clinic.
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Details
- Title
- Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma
- Creators
- Xiaoli Cai - Washington State UniversityMingming Wang - Pacific Northwest National LaboratoryPeng Mu - Pacific Northwest National LaboratoryTengyue Jian - Pacific Northwest National LaboratoryDong Liu - Washington State UniversityShichao Ding - Washington State UniversityYanan Luo - Washington State UniversityDan Du - Washington State UniversityYang Song - Washington State UniversityChun-Long Chen - Pacific Northwest National LaboratoryYuehe Lin - Washington State University
- Publication Details
- Research (Washington), Vol.2021, p.9861384
- Academic Unit
- School of Mechanical and Materials Engineering
- Identifiers
- 99901227841901842
- Language
- English
- Resource Type
- Journal article