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CC BY V4.0, Open Access
Journal article
Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium
Frontiers in oncology, Vol.1(5), pp.13-13
2011
Handle:
https://hdl.handle.net/2376/112855
PMCID: PMC3356135
PMID: 22655231
Abstract
Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American, and Asia case–control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR = 0.79, 95% CI = 0.68–0.93), XRCC1 Arg194Trp homozygotes Arg/Arg (OR = 2.3, 95% CI = 1.1–4.7),
ADH1B
Arg48His homozygotes Arg/Arg (OR = 2.7, 95% CI = 1.9–4.0),
ADH1C
Ile350Val homozygotes Ile/Ile (OR = 1.2, 95% CI = 1.1–1.4), and the
GSTM1
null genotype (OR = 1.1, 95% CI = 1.0–1.2). Among these results,
MGMT
Leu84Phe,
ADH1B
Arg48His,
ADH1C
Ile350Arg, and the
GSTM1
null genotype had fairly low false positive report probabilities (<20%). We observed associations between
ADH1B
Arg48His,
ADH1C
Ile350Arg, and
GSTM1
null genotype and head and neck cancer risk. No functional study currently supports the observed association for
MGMT
Leu84Phe, and the association with
XRCC1
Arg194Trp may be a chance finding.
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Details
- Title
- Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium
- Creators
- Shu-Chun Chuang - Lifestyle and Cancer Group, International Agency for Research on CancerAntonio Agudo - Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, Hospitalet de LlobregatWolfgang Ahrens - Bremen Institute for Prevention Research and Social MedicineDevasena Anantharaman - Cancer Research Institute, Advanced Centre for Treatment, Research, and Education in Cancer, Tata Memorial CenterSimone Benhamou - Unité 794, INSERMStefania Boccia - Institute of Hygiene, Università Cattolica del Sacro CuoreChu Chen - Fred Hutchinson Cancer Research CenterDavid I Conway - Dental School, College of Medical, Veterinary and Life Sciences, University of GlasgowEleonora Fabianova - Department of Occupational Health, Specialized State Health InstituteRichard B Hayes - New York University School of MedicineClaire M Healy - School of Dental Science, Trinity College DublinIvana Holcatova - First Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles UniversityKristina Kjaerheim - Cancer Registry of Norway, Institute for Population-Based Cancer ResearchPagona Lagiou - Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of AthensPhilip Lazarus - Penn State College of MedicineTatiana V Macfarlane - School of Medicine and Dentistry, University of AberdeenManoj B Mahimkar - Cancer Research Institute, Advanced Centre for Treatment, Research, and Education in Cancer, Tata Memorial CenterDana Mates - Occupational Health Department, Institute of Public HealthKeitaro Matsuo - Division of Epidemiology and Prevention, Aichi Cancer Center Research InstituteFranco Merletti - Cancer Epidemiology Unit, University of TurinAndres Metspalu - Laboratory of Gene Technology, Estonian BiocentreHal Morgenstern - Department of Epidemiology, Comprehensive Cancer Center, University of MichiganJoshua Muscat - Penn State College of MedicineGabriella Cadoni - Institute of Otorhinolaryngology, Catholic University of the Sacred HeartAndrew F Olshan - School of Public Health, University of North CarolinaMark Purdue - National Cancer InstituteHeribert Ramroth - Institute of Public Health, University of HeidelbergPeter Rudnai - Fodor József National Center for Public Health, National Institute of Environmental HealthStephen M Schwartz - Fred Hutchinson Cancer Research CenterLorenzo Simonato - Department of Environmental Medicine and Public Health, University of PadovaElaine M Smith - College of Public Health, University of IowaErich M Sturgis - University of Texas MD Anderson Cancer CenterNeonilia Szeszenia-Dabrowska - Institute of Occupational MedicineRenato Talamini - Epidemiology Unit, Aviano Cancer CentrePeter Thomson - Oral and Maxillofacial Surgery School of Dental Sciences, Newcastle UniversityQingyi Wei - University of Texas MD Anderson Cancer CenterDavid Zaridze - Cancer Research Centre, Institute of CarcinogenesisZuo-Feng Zhang - Department of Epidemiology, University of California Los Angeles, School of Public HealthAriana Znaor - Croatian National Cancer Registry, Croatian National Institute of Public HealthPaul Brennan - Lifestyle and Cancer Group, International Agency for Research on CancerPaolo Boffetta - Lifestyle and Cancer Group, International Agency for Research on CancerMia Hashibe - Lifestyle and Cancer Group, International Agency for Research on Cancer
- Publication Details
- Frontiers in oncology, Vol.1(5), pp.13-13
- Academic Unit
- Department of Pharmaceutical Sciences
- Publisher
- Frontiers Research Foundation
- Identifiers
- 99900547689501842
- Language
- English
- Resource Type
- Journal article