Journal article
Sequence and structural analysis of the presumed downstream promoter of the canine mdr1 gene
Veterinary & comparative oncology, Vol.1(1), pp.30-35
03/2003
Handle:
https://hdl.handle.net/2376/114890
PMID: 19379328
Abstract
The product of the canine mdr1 gene, P-glycoprotein (P-gp), plays an important role in chemotherapeutic drug resistance of several canine tumours. Increased expression of P-gp by tumour cells is associated with the multidrug-resistant phenotype. Because of its importance in cancer chemotherapy, a great deal is known about the regulation of mdr1 gene expression in human cancer patients and rodent cancer models. In contrast, there is no information regarding the regulation of P-gp expression in dogs. Initial information regarding the regulation of mdr1 gene expression can be gained by evaluating the mdr1 promoter. The downstream promoter of the canine mdr1 gene was sequenced. Several regulatory elements were identified, including an AP-1 site, AP-2 site and SP-1 site. The presumed canine mdr1 promoter was similar to that of other species; however, low overall sequence homology may suggest that aspects of P-gp regulation are distinctive in dogs.
Metrics
8 Record Views
Details
- Title
- Sequence and structural analysis of the presumed downstream promoter of the canine mdr1 gene
- Creators
- K L Mealey - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6610, USA. kmealey@vetmed.wsu.eduS A Bentjen
- Publication Details
- Veterinary & comparative oncology, Vol.1(1), pp.30-35
- Academic Unit
- Veterinary Clinical Sciences, Department of
- Publisher
- England
- Identifiers
- 99900547815501842
- Language
- English
- Resource Type
- Journal article