Journal article
Sequencing DNA by dynamic force spectroscopy: limitations and prospects
Nano letters, Vol.6(7), pp.1483-1486
07/2006
Handle:
https://hdl.handle.net/2376/116592
PMID: 16834434
Abstract
Using a well established model, we systematically analyze fundamental limitations on the viability of using mechanical unzipping of DNA as a fast and inexpensive sequencing method. Standard unzipping techniques, where double-stranded DNA is unzipped through the application of a force at one end of the molecule, are shown to be inadequate. Emerging techniques that unzip DNA by local force application are more promising, and we establish the necessary experimental requirements that must be met for these techniques to succeed as single molecule sequencing tools.
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Details
- Title
- Sequencing DNA by dynamic force spectroscopy: limitations and prospects
- Creators
- N K Voulgarakis - Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, New Mexico 87545, USAA RedondoA R BishopK O Rasmussen
- Publication Details
- Nano letters, Vol.6(7), pp.1483-1486
- Academic Unit
- Mathematics and Statistics, Department of
- Publisher
- United States
- Identifiers
- 99900547665101842
- Language
- English
- Resource Type
- Journal article