Journal article
Serial Regulation of Transcriptional Regulators in the Yeast Cell Cycle
Cell (Cambridge), Vol.106(6), pp.697-708
2001
Handle:
https://hdl.handle.net/2376/114538
PMID: 11572776
Abstract
Genome-wide location analysis was used to determine how the yeast cell cycle gene expression program is regulated by each of the nine known cell cycle transcriptional activators. We found that cell cycle transcriptional activators that function during one stage of the cell cycle regulate transcriptional activators that function during the next stage. This serial regulation of transcriptional activators forms a connected regulatory network that is itself a cycle. Our results also reveal how the nine transcriptional regulators coordinately regulate global gene expression and diverse stage-specific functions to produce a continuous cycle of cellular events. This information forms the foundation for a complete map of the transcriptional regulatory network that controls the cell cycle.
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Details
- Title
- Serial Regulation of Transcriptional Regulators in the Yeast Cell Cycle
- Creators
- Itamar Simon - Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142 USAJohn Barnett - Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142 USANancy Hannett - Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142 USAChristopher T Harbison - Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142 USANicola J Rinaldi - Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142 USAThomas L Volkert - Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142 USAJohn J Wyrick - Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142 USAJulia Zeitlinger - Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142 USADavid K Gifford - MIT Artificial Intelligence Laboratory, 200 Technology Square, Cambridge, MA 02139 USATommi S Jaakkola - MIT Artificial Intelligence Laboratory, 200 Technology Square, Cambridge, MA 02139 USARichard A Young - Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142 USA
- Publication Details
- Cell (Cambridge), Vol.106(6), pp.697-708
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- Elsevier Inc
- Identifiers
- 99900548145401842
- Language
- English
- Resource Type
- Journal article