Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma

Abdel-Rahman N Zekri; Abeer A Bahnassy; Hanaa M Alam El-Din; Heba M Morsy; Sabry Shaarawy; Nagia Z Moharram; Sayed S Daoud

doi:10.3892/or.2011.1355

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Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma

Journal article

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Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma

Abdel-Rahman N Zekri, Abeer A Bahnassy, Hanaa M Alam El-Din, Heba M Morsy, Sabry Shaarawy, Nagia Z Moharram and Sayed S Daoud

Oncology reports, Vol.26(4), pp.825-831

10/2011

DOI: https://doi.org/10.3892/or.2011.1355

Handle:

https://hdl.handle.net/2376/110115

PMID: 21701780

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Abstract

Osteopontin - blood

Humans

Middle Aged

Cadherins - blood

Hepacivirus - genetics

Male

Liver Neoplasms - blood

beta Catenin - blood

Hepatitis C - blood

Adult

Female

Hepatitis C - complications

Intercellular Adhesion Molecule-1 - blood

Carcinoma, Hepatocellular - blood

Liver Neoplasms - virology

Enzyme-Linked Immunosorbent Assay

Carcinoma, Hepatocellular - diagnosis

Risk Factors

Genotype

Carcinoma, Hepatocellular - virology

Biomarkers, Tumor - blood

Matrix Metalloproteinase 2 - blood

Liver Neoplasms - diagnosis

Hepatitis C - virology

Aged

Vascular Endothelial Growth Factor Receptor-1 - blood

The global rising incidence of hepatocellular carcinoma (HCC), which parallels the increase of hepatitis C virus (HCV) prevalence, has sparked a renewed interest in discovering additional HCC serum markers. In this study, we investigated the clinical use of serum E-cadherin, ICAM, MMP-2, VEGF, OPN and β-catenin as potential diagnostic makers for HCV/genotype 4-associated HCC. Twenty cases of healthy subjects, 11 cases with asymptomatic HCV/genotype 4 carriers (ASC), 28 chronic hepatitis (CH) cases and 32 patients with HCC were enrolled in this study. Serum levels of proteins were measured by a sandwich-enzyme-linked (ELISA) assay. The diagnostic accuracy of each candidate marker was evaluated using receiver-operating characteristic (ROC) curve analysis, reporting the area under the curve (AUC) and its 95% confidence interval (CI). We demonstrated that serum β-catenin levels were significantly elevated in patients with HCC compared to those with CH, ASC and healthy controls. Among the six studied markers, β-catenin was also found to be the only marker that can significantly discriminate between patients with HCC and those with CH; therefore, β-catenin could be considered as a potential marker for early diagnosis of HCV-associated HCC in patients infected with HCV genotype 4.

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Title: Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma
Creators: Abdel-Rahman N Zekri - Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
Abeer A Bahnassy
Hanaa M Alam El-Din
Heba M Morsy
Sabry Shaarawy
Nagia Z Moharram
Sayed S Daoud
Publication Details: Oncology reports, Vol.26(4), pp.825-831
Academic Unit: Pharmaceutical Sciences, Department of
Publisher: Greece
Identifiers: 99900547152701842
Language: English
Resource Type: Journal article