Journal article
Sex, Not Genotype, Determines Recombination Levels in Mice
American journal of human genetics, Vol.77(4), pp.670-675
10/2005
Handle:
https://hdl.handle.net/2376/103873
PMCID: PMC1275616
PMID: 16175513
Abstract
Recombination, the precise physical breakage and rejoining of DNA between homologous chromosomes, plays a central role in mediating the orderly segregation of meiotic chromosomes in most eukaryotes. Despite its importance, the factors that control the number and placement of recombination events within a cell remain poorly defined. The rate of recombination exhibits remarkable species specificity, and, within a species, recombination is affected by the physical size of the chromosome, chromosomal location, proximity to other recombination events (i.e., chiasma interference), and, intriguingly, the sex of the transmitting parent. To distinguish between simple genetic and nongenetic explanations of sex-specific recombination differences in mammals, we compared recombination in meiocytes from XY sex-reversed and XO females with that in meiocytes from XX female and XY male mice. The rate and pattern of recombination in XY and XO oocytes were virtually identical to those in normal XX females, indicating that sex, not genotype, is the primary determinant of meiotic recombination patterns in mammals.
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Details
- Title
- Sex, Not Genotype, Determines Recombination Levels in Mice
- Creators
- Audrey Lynn - Department of Genetics, Case Western Reserve University, ClevelandStefanie Schrump - Department of Genetics, Case Western Reserve University, ClevelandJonathan Cherry - Department of Genetics, Case Western Reserve University, ClevelandTerry Hassold - Department of Genetics, Case Western Reserve University, ClevelandPatricia Hunt - Department of Genetics, Case Western Reserve University, Cleveland
- Publication Details
- American journal of human genetics, Vol.77(4), pp.670-675
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- The American Society of Human Genetics
- Identifiers
- 99900546954801842
- Language
- English
- Resource Type
- Journal article