Journal article
Short‐Term Clarithromycin Administration Impairs Clearance and Enhances Pharmacodynamic Effects of Trazodone but Not of Zolpidem
Clinical pharmacology and therapeutics, Vol.85(6), pp.644-650
06/2009
Handle:
https://hdl.handle.net/2376/107209
PMID: 19242403
Abstract
The kinetic and dynamic interactions of 5 mg zolpidem and 50 mg trazodone with 500 mg clarithromycin (4 doses given over 32 h) were investigated in a 5‐way double crossover study with 10 healthy volunteers. The five treatment conditions were: placebo + placebo; zolpidem + placebo; zolpidem + clarithromycin; trazodone + placebo; and trazodone + clarithromycin. Coadministration of clarithromycin increased trazodone area under the curve, prolonged elimination half‐life, increased peak plasma concentration (Cmax), and reduced oral clearance. In contrast, clarithromycin had no significant effect on any kinetic parameter for zolpidem. Clarithromycin did not potentiate sedation caused by zolpidem. However, clarithromycin coadministered with trazodone significantly increased self‐ and observer‐rated sedation and ratings of feeling “spacey.” Thus, short‐term clarithromycin coadministration significantly impairs trazodone clearance, elevates plasma concentrations, and enhances sedative effects. However, clarithromycin has no significant kinetic or dynamic interaction with zolpidem.
Clinical Pharmacology & Therapeutics (2009); 85, 6, 644–650 doi:10.1038/clpt.2008.293
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Details
- Title
- Short‐Term Clarithromycin Administration Impairs Clearance and Enhances Pharmacodynamic Effects of Trazodone but Not of Zolpidem
- Creators
- D Farkas - Tufts University School of Medicine and Tufts Medical CenterL P Volak - Tufts University School of Medicine and Tufts Medical CenterJ S Harmatz - Tufts University School of Medicine and Tufts Medical CenterL L Moltke - Tufts University School of Medicine and Tufts Medical CenterM H Court - Tufts University School of Medicine and Tufts Medical CenterD J Greenblatt - Tufts University School of Medicine and Tufts Medical Center
- Publication Details
- Clinical pharmacology and therapeutics, Vol.85(6), pp.644-650
- Academic Unit
- Veterinary Clinical Sciences, Department of
- Number of pages
- 7
- Grant note
- Sanofi‐Aventis Department of Health and Human Services (AT‐003540; AT‐003973; GM‐061834; AI‐058784; GM‐074369; AG‐017880)
- Identifiers
- 99900546503301842
- Language
- English
- Resource Type
- Journal article