Journal article
Single-Atomic Iron Doped Carbon Dots with Both Photoluminescence and Oxidase-Like Activity
Small (Weinheim an der Bergstrasse, Germany), Vol.18(37), pp.e2203001-n/a
09/01/2022
PMID: 35986440
Abstract
Multifunctional nanozymes can benefit biochemical analysis via expanding sensing modes and enhancing analytical performance, but designing multifunctional nanozymes to realize the desired sensing of targets is challenging. In this work, single-atomic iron doped carbon dots (SA Fe-CDs) are designed and synthesized via a facile in situ pyrolysis process. The small-sized CDs not only maintain their tunable fluorescence, but also serve as a support for loading dispersed active sites. Monoatomic Fe offers SA Fe-CDs exceptional oxidase-mimetic activity to catalyze 3,3 ',5,5 '-tetramethylbenzidine (TMB) oxidation with fast response (V-max = 10.4 nM s(-1)) and strong affinity (K-m = 168 mu M). Meanwhile, their photoluminescence is quenched by the oxidation product of TMB due to inner filter effect. Phosphate ions (Pi) can suppress the oxidase-mimicking activity and restore the photoluminescence of SA Fe-CDs by interacting with Fe active sites. Based on this principle, a dual-mode colorimetric and fluorescence assay of Pi with high sensitivity, selectivity, and rapid response is established. This work paves a path to develop multifunctional enzyme-like catalysts, and offers a simple but efficient dual-mode method for phosphate monitoring, which will inspire the exploration of multi-mode sensing strategies based on nanozyme catalysis.
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Details
- Title
- Single-Atomic Iron Doped Carbon Dots with Both Photoluminescence and Oxidase-Like Activity
- Creators
- Xin Li - Jiangsu UniversityShichao Ding - Washington State UniversityZhaoyuan Lyu - Washington State UniversityPeter Tieu - University of California, IrvineMaoyu Wang - Oregon State UniversityZhenxing Feng - Oregon State UniversityXiaoqing Pan - University of California, IrvineYang Zhou - Washington State UniversityXiangheng Niu - Jiangsu UniversityDan Du - Washington State UniversityWenlei Zhu - Washington State UniversityYuehe Lin - Washington State University
- Publication Details
- Small (Weinheim an der Bergstrasse, Germany), Vol.18(37), pp.e2203001-n/a
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- CBET-2031494; CBET-2031512 / National Science Foundation (NSF) 201908320292 / China Scholarship Council Washington State University
- Identifiers
- 99901227841001842
- Language
- English
- Resource Type
- Journal article