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CC BY V4.0, Open Access
Journal article
Single-atom materials boosting wearable orthogonal uric acid detection
Med-X, Vol.2(1), 12
09/20/2024
Abstract
Uric acid (UA) is a vital biomarker for the diagnosis and management of various health conditions, including cardiovascular diseases, gout, kidney disorders, metabolic syndrome, and wound healing. Despite significant advances in wearable sensor technology, challenges persist in developing wearable sensors that are capable of maintaining high sensitivity, selectivity, and stability. In this study, we present an epidermal sensing platform enhanced with single-atom materials (SAMs) designed for flexible and orthogonal electrochemical detection of UA. We designed and synthesized an SAM with Fe-N
5
active sites to boost the electrochemical sensing signals, integrating it with laser-engraved graphene (LEG) to fabricate a wearable SAM-based UA patch sensor. This design provides superior UA detection performance compared to sensors based on conventional nanomaterials. In addition, we enhanced the detection accuracy and range by using an orthogonal approach that combines direct oxidation through differential pulse voltammetry (DPV) along with parallel biocatalytic amperometric detection. The resulting SAM-based UA orthogonal sensor patch demonstrated exceptional performance in wearable applications through tests measuring sweat UA levels in subjects before and after consuming a purine-rich diet.
Graphical Abstract
Highlight
• A novel single-atom material (SAM) designed with Fe-N
5
active sites is combined with a laser-engraved graphene electrode to boost highly sensitive uric acid (UA) detection.
• The fabricated SAM-based UA patch sensor exhibits good flexibility and wearability.
• An orthogonal detection approach is utilized, integrating differential pulse voltammetry with biocatalytic amperometric detection, to achieve enhanced accuracy and selectivity in uric acid measurements.
• The SAM-based UA patch sensor has been successfully tested in on-body sweat sensing towards UA, demonstrating its practicality for wearable applications .
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Details
- Title
- Single-atom materials boosting wearable orthogonal uric acid detection
- Creators
- Shichao Ding - University of California, San DiegoSitao Li - University of California, San DiegoZhaoyuan Lyu - Washington State UniversityJiachi Zhou - University of California, San DiegoSelene Tang - University of California, San DiegoLingzhe Fang - Northern Illinois UniversityWenjie Zang - University of California, IrvinePengtao Zhang - University of California, San DiegoSunjae Kim - University of California, San DiegoTao Li - Northern Illinois UniversityXiaoqing Pan - University of California, IrvineDan Du - Washington State UniversityYuehe Lin - School of Mechanical and Materials Engineering, Washington State UniversityJoseph Wang - University of California, San Diego
- Publication Details
- Med-X, Vol.2(1), 12
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Springer Nature Singapore
- Grant note
- DE-AC02-06CH11357 / Office of Science (http://dx.doi.org/10.13039/100006132) Washington State University (http://dx.doi.org/10.13039/100007588) 1 R01OH012579-01-00 / National Institute for Occupational Safety and Health (http://dx.doi.org/10.13039/100000125) DMR-2011967 / National Science Foundation (http://dx.doi.org/10.13039/100000001) University of California-San Diego (http://dx.doi.org/10.13039/100023741)
- Identifiers
- 99901227843401842
- Language
- English
- Resource Type
- Journal article