Journal article
Single perturbed beat vs. steady-state beats for assessing systolic function in the isolated heart
The American journal of physiology, Vol.262(6 Pt 2), pp.H1631-H1639
06/1992
Handle:
https://hdl.handle.net/2376/113925
PMID: 1621824
Abstract
Single-beat and steady-state techniques for evaluating end-systolic pressure-volume relationship (ESPVR) and Frank-Starling mechanism (FSM) in the crystalloid-perfused isolated rabbit heart were compared. In the single-beat technique, a train of stable isovolumic beats was interrupted with a single perturbed beat that either ejected against various levels of imposed isobaric load (ESPVR protocol) or beat isovolumically against various levels of end-diastolic volume (V(ED); FSM protocol). In steady-state technique, sustained beating was established, isobarically, at each of various loads (ESPVR protocol) or, isovolumically, at each of various V(ED) values (FSM protocol). ESPVR from steady-state technique lay above and to the left of that from single-beat technique. Contractile state was not uniform within steady-state technique, whereas it was uniform within single-beat technique. In the FSM protocol, single-beat technique exhibited the following features relative to steady-state technique: 1) greater range of developed pressures, 2) steeper ascending limb and more sharply defined maxima, 3) higher maximal developed pressure (Pdmax), and 4) greater volume at Pdmax(Vmax). Again. a common contractile state existed within single-beat technique but not within steady-state technique. It was concluded that single-beat technique was preferable to steady-state technique for evaluating ESPVR and FSM because 1) single-beat technique required less time for obtaining data, 2) single-beat technique allowed identification of uncomplicated values of Pdmax and Vmax, and 3) single-beat technique provided a common contractile-state reference for all data, whereas steady-state technique did not.
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Details
- Title
- Single perturbed beat vs. steady-state beats for assessing systolic function in the isolated heart
- Creators
- K B Campbell - Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman 99164-6520H TaheriR D KirkpatrickB K Slinker
- Publication Details
- The American journal of physiology, Vol.262(6 Pt 2), pp.H1631-H1639
- Academic Unit
- Veterinary Medicine, College of; Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- HL-21462 / NHLBI NIH HHS HL-37005 / NHLBI NIH HHS
- Identifiers
- 99900548132101842
- Language
- English
- Resource Type
- Journal article