Journal article
Sleep and Microbes
International review of neurobiology, Vol.131, pp.207-225
2016
Handle:
https://hdl.handle.net/2376/113579
PMCID: PMC5441385
PMID: 27793219
Abstract
Sleep is profoundly altered during the course of infectious diseases. The typical response to infection includes an initial increase in nonrapid eye movement sleep (NREMS) followed by an inhibition in NREMS. REMS is inhibited during infections. Bacterial cell wall components, such as peptidoglycan and lipopolysaccharide, macrophage digests of these components, such as muramyl peptides, and viral products, such as viral double-stranded RNA, trigger sleep responses. They do so via pathogen-associated molecular pattern recognition receptors that, in turn, enhance cytokine production. Altered sleep and associated sleep-facilitated fever responses are likely adaptive responses to infection. Normal sleep in physiological conditions may also be influenced by gut microbes because the microbiota is affected by circadian rhythms, stressors, diet, and exercise. Furthermore, sleep loss enhances translocation of viable bacteria from the intestine, which provides another means by which sleep-microbe interactions impact neurobiology.
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Details
- Title
- Sleep and Microbes
- Creators
- J M Krueger - Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, United States. Electronic address: krueger@vetmed.wsu.eduM R Opp - University of Washington College of Medicine, Seattle, WA, United States
- Publication Details
- International review of neurobiology, Vol.131, pp.207-225
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- R21 AI115706 / NIAID NIH HHS R01 NS025378 / NINDS NIH HHS R01 AG041287 / NIA NIH HHS R01 HD036520 / NICHD NIH HHS
- Identifiers
- 99900547307901842
- Language
- English
- Resource Type
- Journal article