Journal article
Sleep as a fundamental property of neuronal assemblies
Nature reviews. Neuroscience, Vol.9(12), pp.910-919
12/2008
Handle:
https://hdl.handle.net/2376/115130
PMCID: PMC2586424
PMID: 18985047
Abstract
Sleep is vital to cognitive performance, productivity, health and well-being. Earlier theories of sleep presumed that it occurred at the level of the whole organism and that it was governed by central control mechanisms. However, evidence now indicates that sleep might be regulated at a more local level in the brain: it seems to be a fundamental property of neuronal networks and is dependent on prior activity in each network. Such local-network sleep might be initiated by metabolically driven changes in the production of sleep-regulatory substances. We discuss a mathematical model which illustrates that the sleep-like states of individual cortical columns can be synchronized through humoral and electrical connections, and that whole-organism sleep occurs as an emergent property of local-network interactions.
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Details
- Title
- Sleep as a fundamental property of neuronal assemblies
- Creators
- James M Krueger - Department of VCAPP, College of Veterinary Medicine, Washington State University, PO BOX 646520, Pullman, Washington 99164-6520, USA. Krueger@vetmed.wsu.eduDavid M RectorSandip RoyHans P A Van DongenGregory BelenkyJaak Panksepp
- Publication Details
- Nature reviews. Neuroscience, Vol.9(12), pp.910-919
- Academic Unit
- Medical Education and Clinical Science, Department of; Integrative Physiology and Neuroscience, Department of; Electrical Engineering and Computer Science, School of
- Publisher
- England
- Grant note
- NS 31453 / NINDS NIH HHS MH 71830 / NIMH NIH HHS R01 NS025378-21 / NINDS NIH HHS R01 NS025378 / NINDS NIH HHS R01 MH071830-03 / NIMH NIH HHS R01 MH071830 / NIMH NIH HHS R01 NS031453 / NINDS NIH HHS NS 25378 / NINDS NIH HHS R01 NS031453-15 / NINDS NIH HHS
- Identifiers
- 99900547789501842
- Language
- English
- Resource Type
- Journal article