Journal article
Sleep, clocks, and synaptic plasticity
Trends in neurosciences (Regular ed.), Vol.37(9), pp.491-501
09/2014
Handle:
https://hdl.handle.net/2376/111189
PMCID: PMC4152403
PMID: 25087980
Abstract
•Sleep does not have a single effect on synapses.•The effects of sleep vary across brain regions and species.•Circadian factors independently influence synaptic efficacy and morphology.•Sleep and circadian rhythms interact to strengthen and weaken synapses.
Sleep is widely believed to play an essential role in synaptic plasticity. However, the precise mechanisms governing this presumptive function are largely unknown. There is also evidence for independent circadian oscillations in synaptic strength and morphology. Therefore, synaptic changes observed after sleep reflect interactions between state-dependent (e.g., wake versus sleep) and state-independent (circadian) processes. In this review we consider how sleep and biological clocks influence synaptic plasticity. We discuss these findings in the context of current plasticity-based theories of sleep function and propose a new model that integrates circadian and brain-state influences on synaptic plasticity.
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Details
- Title
- Sleep, clocks, and synaptic plasticity
- Creators
- Marcos G Frank - Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USARafael Cantera - Zoology Department, Stockholm University, Stockholm, Sweden
- Publication Details
- Trends in neurosciences (Regular ed.), Vol.37(9), pp.491-501
- Academic Unit
- Biomedical Sciences, Department of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900547343701842
- Language
- English
- Resource Type
- Journal article