Journal article
Sleep loss alters hypothalamic growth hormone-releasing hormone receptors in rats
Neuroscience letters, Vol.329(1), pp.69-72
2002
Handle:
https://hdl.handle.net/2376/101657
PMID: 12161265
Abstract
Previous experiments suggest that sleep deprivation (SD) is associated with growth hormone-releasing hormone (GHRH) release and that GHRH promotes sleep via intrahypothalamic sites of action. Binding of [His
1,
125I-Tyr
10, Nle
27]hGHRH(1–32) amide and GHRH receptor (GHRH-R) mRNA levels were determined in the hypothalamus and pituitary of rats subjected to 8 h of SD and of undisturbed control rats. The characteristics of the hypothalamic GHRH binding sites differed from those of the pituitary. High affinity GHRH binding and GHRH-R mRNA levels decreased by 50% in the hypothalamus of SD rats, whereas there were no alterations in the pituitary. The results demonstrate that GHRH-Rs exist in the hypothalamus and they respond differently to SD than the GHRH-Rs in the pituitary. The SD-induced changes are explained by down-regulation of the hypothalamic GHRH-Rs induced by GHRH release during and after SD.
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Details
- Title
- Sleep loss alters hypothalamic growth hormone-releasing hormone receptors in rats
- Creators
- J Gardi - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, P.O. Box 646520, Pullman, WA, USAP Taishi - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, P.O. Box 646520, Pullman, WA, USAR Speth - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, P.O. Box 646520, Pullman, WA, USAF Obal - Department of Physiology, A. Szent-Györgyi Medical Center, University of Szeged, Szeged, HungaryJ.M Krueger - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, P.O. Box 646520, Pullman, WA, USA
- Publication Details
- Neuroscience letters, Vol.329(1), pp.69-72
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Ireland Ltd
- Identifiers
- 99900546800401842
- Language
- English
- Resource Type
- Journal article