Sleep loss alters synaptic and intrinsic neuronal properties in mouse prefrontal cortex

Bradley D Winters; Yanhua H Huang; Yan Dong; James M Krueger

doi:10.1016/j.brainres.2011.08.078

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Sleep loss alters synaptic and intrinsic neuronal properties in mouse prefrontal cortex

Journal article

Open access

Peer reviewed

Sleep loss alters synaptic and intrinsic neuronal properties in mouse prefrontal cortex

Bradley D Winters, Yanhua H Huang, Yan Dong and James M Krueger

Brain research, Vol.1420, pp.1-7

10/28/2011

DOI: https://doi.org/10.1016/j.brainres.2011.08.078

Handle:

https://hdl.handle.net/2376/102913

PMCID: PMC3205322

PMID: 21962531

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https://doi.org/10.1016/j.brainres.2011.08.078View

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Abstract

Electric Stimulation

Pyramidal Cells - physiopathology

Eye Movements

Sleep Deprivation - pathology

Mice, Inbred C57BL

Male

Electroencephalography

Excitatory Postsynaptic Potentials - drug effects

Prefrontal Cortex - pathology

Action Potentials - physiology

Excitatory Postsynaptic Potentials - physiology

Patch-Clamp Techniques

Sleep Deprivation - physiopathology

Animals

Analysis of Variance

Time Factors

Mice

Pyramidal Cells - drug effects

Action Potentials - drug effects

Despite sleep-loss-induced cognitive deficits, little is known about the cellular adaptations that occur with sleep loss. We used brain slices obtained from mice that were sleep deprived for 8h to examine the electrophysiological effects of sleep deprivation (SD). We employed a modified pedestal (flowerpot) over water method for SD that eliminated rapid eye movement sleep and greatly reduced non-rapid eye movement sleep. In layer V/VI pyramidal cells of the medial prefrontal cortex, miniature excitatory post synaptic current amplitude was slightly reduced, miniature inhibitory post synaptic currents were unaffected, and intrinsic membrane excitability was increased after SD.

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Title: Sleep loss alters synaptic and intrinsic neuronal properties in mouse prefrontal cortex
Creators: Bradley D Winters - Program in Neuroscience, Washington State University, Pullman, WA 99164-6520, USA. bwinters@vetmed.wsu.edu
Yanhua H Huang
Yan Dong
James M Krueger
Publication Details: Brain research, Vol.1420, pp.1-7
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: Netherlands
Grant note: R37 DA023206 / NIDA NIH HHS NS025378 / NINDS NIH HHS K99 DA029565 / NIDA NIH HHS DA023206 / NIDA NIH HHS NS031453 / NINDS NIH HHS R01 NS025378 / NINDS NIH HHS R01 NS031453-18 / NINDS NIH HHS R01 NS031453 / NINDS NIH HHS R01 DA023206 / NIDA NIH HHS R01 NS025378-25 / NINDS NIH HHS
Identifiers: 99900546552201842
Language: English
Resource Type: Journal article