Journal article
Sleep of transgenic mice producing excess rat growth hormone
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.282(1), pp.R70-R76
01/01/2002
Handle:
https://hdl.handle.net/2376/115925
PMID: 11742825
Abstract
The effects of chronic excess of growth hormone (GH) on sleep-wake activity was determined in giant transgenic mice in which the metallothionein-1 promoter stimulates the expression of rat GH (MT-rGH mice) and in their normal littermates. In the MT-rGH mice, the time spent in spontaneous non-rapid eye movement sleep (NREMS) was enhanced moderately, and rapid eye movement sleep (REMS) time increased greatly during the light period. After a 12-h sleep deprivation, the MT-rGH mice continued to sleep more than the normal mice, but there were no differences in the increments in NREMS, REMS, and electroencephalogram (EEG) slow-wave activity (SWA) during NREMS between the two groups. Injection of the somatostatin analog octreotide elicited a prompt sleep suppression followed by increases in SWA during NREMS in normal mice. These changes were attenuated in the MT-rGH mice. The decreased responsiveness to octreotide is explained by a chronic suppression of hypothalamic GH-releasing hormone in the MT-rGH mice. Enhancements in spontaneous REMS are attributed to the REMS-promoting activity of GH. The increases in spontaneous NREMS are, however, not consistent with our current understanding of the role of somatotropic hormones in sleep regulation. Metabolic, neurotransmitter, or hormonal changes associated with chronic GH excess may indirectly influence sleep.
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Details
- Title
- Sleep of transgenic mice producing excess rat growth hormone
- Creators
- I Hajdu - Department of Physiology, University of Szeged, A. Szent-Györgyi Medical Center, 6720 Szeged, Hungary;, Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, Washington 99164-6520; andF Obal - Department of Physiology, University of Szeged, A. Szent-Györgyi Medical Center, 6720 Szeged, HungaryJ Fang - Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, Washington 99164-6520; andJ. M Krueger - Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, Washington 99164-6520; andC. D Rollo - Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.282(1), pp.R70-R76
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900547822001842
- Language
- English
- Resource Type
- Journal article