Journal article
Sleep-promoting effects of endogenous pyrogen (interleukin-1)
The American journal of physiology, Vol.246(6 Pt 2), pp.R994-999
06/1984
Handle:
https://hdl.handle.net/2376/117538
PMID: 6611091
Abstract
When infused into the lateral cerebral ventricles of rabbits, human endogenous pyrogen (EP) preparations induced dose-dependent increases in slow-wave sleep concomitant with increasing body temperature. Heating EP to 70 degrees C destroyed its sleep-promoting and pyrogenic activity. Anisomycin (an antipyretic) prevented EP from increasing body temperature without affecting its sleep-promoting activity. Intravenous injection of EP induced fever and transient increases in slow-wave sleep but failed to induce prolonged increases in slow-wave sleep. We conclude that the somnogenic activity of EP is not secondary to its pyrogenic activity.
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Details
- Title
- Sleep-promoting effects of endogenous pyrogen (interleukin-1)
- Creators
- J M KruegerJ WalterC A DinarelloS M WolffL Chedid
- Publication Details
- The American journal of physiology, Vol.246(6 Pt 2), pp.R994-999
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- NIH-BRSG-RR5366 / NCRR NIH HHS NIH-AI-15614 / NIAID NIH HHS
- Identifiers
- 99900548195801842
- Language
- English
- Resource Type
- Journal article