Journal article
Sleep-promoting effects of muramyl peptides
Proceedings of the National Academy of Sciences - PNAS, Vol.79(19), pp.6102-6106
10/1982
Handle:
https://hdl.handle.net/2376/104978
PMCID: PMC347061
PMID: 6964403
Abstract
A muramyl peptide that induces excess slow-wave sleep in rats, rabbits, and cats has recently been isolated from human urine. We now report that synthetic acetylmuramyl-L-alanyl-D-isoglutamine ("muramyl dipeptide") and its lysyl derivative (acetylmuramyl-L-alanyl-D-isoglutaminyllysine) can mimic the somnogenic effects of the natural peptide. Both compounds are also pyrogenic and may cause other disturbances of autonomic function. The pyrogenic effects of intravenously administered muramyl dipeptide can be suppressed by previous treatment with acetaminophen without blocking the sleep-promoting effects.
Metrics
8 Record Views
Details
- Title
- Sleep-promoting effects of muramyl peptides
- Creators
- J M KruegerJ R PappenheimerM L Karnovsky
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.79(19), pp.6102-6106
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- RR-5366 / NCRR NIH HHS
- Identifiers
- 99900546846401842
- Language
- English
- Resource Type
- Journal article