Journal article
Sleep-promoting material from human urine and its relation to factor S from brain
The American journal of physiology, Vol.238(2), pp.E116-123
02/1980
Handle:
https://hdl.handle.net/2376/114331
PMID: 7361888
Abstract
A sleep-promoting factor was extracted from human urine. Intraventricular infusion of the purified material induced excess slow-wave sleep in rats and rabbits for 5--10 h after the infusion. Chemical properties of the urinary factor were similar to those of factor S derived from whole brains of sleep-deprived goats, sheep, and rabbits. The behavior of the urinary factor in two ion exchange chromatographic steps, high voltage electrophoresis, gel-filtration, and ultrafiltration was similar to that of factor S. Effects of the purified urinary factor on slow-wave sleep of rats and rabbits were similar in time-course and duration to those of factor S from brain. However, the factor obtained from human urine did not increase the amplitude of cortical slow waves to the same extent as did factor S from brains of sleep-deprived animals.
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Details
- Title
- Sleep-promoting material from human urine and its relation to factor S from brain
- Creators
- J M KruegerJ BacsikJ García-Arrarás
- Publication Details
- The American journal of physiology, Vol.238(2), pp.E116-123
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Identifiers
- 99900548474601842
- Language
- English
- Resource Type
- Journal article