Journal article
Sleep slow-wave activity regulates cerebral glycolytic metabolism
Cerebral cortex (New York, N.Y. 1991), Vol.23(8), pp.1978-1987
08/2013
Handle:
https://hdl.handle.net/2376/110493
PMCID: PMC3707408
PMID: 22767634
Abstract
Non-rapid eye movement sleep (NREMS) onset is characterized by a reduction in cerebral metabolism and an increase in slow waves, 1-4-Hz oscillations between relatively depolarized and hyperpolarized states in the cerebral cortex. The metabolic consequences of slow-wave activity (SWA) at the cellular level remain uncertain. We sought to determine whether SWA modulates the rate of glycolysis within the cerebral cortex. The real-time measurement of lactate concentration in the mouse cerebral cortex demonstrates that it increases during enforced wakefulness. In spontaneous sleep/wake cycles, lactate concentration builds during wakefulness and rapid eye movement sleep and declines during NREMS. The rate at which lactate concentration declines during NREMS is proportional to the magnitude of electroencephalographic (EEG) activity at frequencies of <10 Hz. The induction of 1-Hz oscillations, but not 10-Hz oscillations, in the electroencephalogram by optogenetic stimulation of cortical pyramidal cells during wakefulness triggers a decline in lactate concentration. We conclude that cerebral SWA promotes a decline in the rate of glycolysis in the cerebral cortex. These results demonstrate a cellular energetic function for sleep SWA, which may contribute to its restorative effects on brain function.
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Details
- Title
- Sleep slow-wave activity regulates cerebral glycolytic metabolism
- Creators
- Jonathan P Wisor - WWAMI Medical Education Program, Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Spokane, WA 99210-1945, USA. j_wisor@wsu.eduMichael J RempeMichelle A SchmidtMichele E MooreWilliam C Clegern
- Publication Details
- Cerebral cortex (New York, N.Y. 1991), Vol.23(8), pp.1978-1987
- Academic Unit
- Biomedical Sciences, Department of
- Publisher
- United States
- Grant note
- R15NS070734 / NINDS NIH HHS R01 NS078498 / NINDS NIH HHS R01NS078498 / NINDS NIH HHS
- Identifiers
- 99900547253201842
- Language
- English
- Resource Type
- Journal article