Slow generation of hydrogen sulfide from sulfane sulfurs and NADH models

Bo Peng; Chunrong Liu; Zhen Li; Jacob J Day; Yun Lu; David J Lefer; Ming Xian

doi:10.1016/j.bmcl.2016.12.023

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Slow generation of hydrogen sulfide from sulfane sulfurs and NADH models

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Slow generation of hydrogen sulfide from sulfane sulfurs and NADH models

Bo Peng, Chunrong Liu, Zhen Li, Jacob J Day, Yun Lu, David J Lefer and Ming Xian

Bioorganic & medicinal chemistry letters, Vol.27(3), pp.542-545

02/01/2017

DOI: https://doi.org/10.1016/j.bmcl.2016.12.023

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https://hdl.handle.net/2376/107236

PMCID: PMC5241217

PMID: 28003140

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Abstract

NAD - chemistry

Hydrogen Sulfide - chemical synthesis

Molecular Structure

Sulfur Compounds - chemistry

Oxidation-Reduction

Hydrogen Sulfide - chemistry

Here we report the model studies of the reactions between NADH models (using HEH and BNAH) and sulfane sulfurs (using polysulfides). Such reactions could lead to the oxidation of NADH models and the production of hydrogen sulfide (H S). Kinetics of the reaction between BNAH and elemental sulfur S were determined in ethanol and the second-order rate constant was found to be 0.074M min (at 37°C) suggesting this is a slow process.

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Title: Slow generation of hydrogen sulfide from sulfane sulfurs and NADH models
Creators: Bo Peng - Department of Chemistry, Washington State University, Pullman, WA 99164, USA
Chunrong Liu - Department of Chemistry, Washington State University, Pullman, WA 99164, USA
Zhen Li - Cardiovascular Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA 70112, USA
Jacob J Day - Department of Chemistry, Washington State University, Pullman, WA 99164, USA
Yun Lu - Department of Chemistry, Southern Illinois University Edwardsville, Edwardsville, IL 62026, USA
David J Lefer - Cardiovascular Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA 70112, USA
Ming Xian - Department of Chemistry, Washington State University, Pullman, WA 99164, USA. Electronic address: mxian@wsu.edu
Publication Details: Bioorganic & medicinal chemistry letters, Vol.27(3), pp.542-545
Academic Unit: Chemistry, Department of
Publisher: England
Grant note: R01 HL116571 / NHLBI NIH HHS P30 GM106392 / NIGMS NIH HHS
Identifiers: 99900547081801842
Language: English
Resource Type: Journal article