Journal article
Smartphone Optosensing Platform Using a DVD Grating to Detect Neurotoxins
ACS sensors, Vol.1(4), pp.366-373
04/22/2016
Abstract
We present a smartphone optosensing platform (SOP) using a digital versatile disc (DVD) diffraction grating for rapid in-field detecting neurotoxins. The smartphone holder and sample holder were 3D printed for the SOP. A DVD grating is demonstrated for the first time in a low-cost miniature spectrometer on the SOP to quantify the concentrations of neurotoxins. The SOP is capable of detecting optical absorbance spectra within the entire visible spectral range from 400 to 700 nm with the spectral resolution of 0.2521 nm/pixel. We demonstrated the performance of the DVD grating compared with a commercial transmission grating on the SOP and a conventional microplate reader. Paraoxon, as the selected neurotoxin model, is assayed by two types of cholinesterase (ChE) on our SOP, respectively. Integrating a DVD grating in the SOP allows quantification of paraoxon in the range from 5 nM to 25 mu M with the detection limit of 2.9 nM. In addition to the low assessed detection limit at medically relevant concentrations, the performance of SOP with DVD gratings provides new avenues for a point-of-care toxin diagnosis with time and cost savings.
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Details
- Title
- Smartphone Optosensing Platform Using a DVD Grating to Detect Neurotoxins
- Creators
- Li-Ju Wang - Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USAYu-Chung Chang - Washington State UniversityXiaoxiao Ge - Washington State UniversityAllison T. Osmanson - Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USADan Du - Washington State UniversityYuehe Lin - Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USALei Li - Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA
- Publication Details
- ACS sensors, Vol.1(4), pp.366-373
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Amer Chemical Soc
- Number of pages
- 8
- Grant note
- R21OH010768 / Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health (CDC/NIOSH) Grant 1538439 / Directorate For Engineering; National Science Foundation (NSF); NSF - Directorate for Engineering (ENG) CMMI-1538439 / National Science Foundation (NSF)
- Identifiers
- 99901227640501842
- Language
- English
- Resource Type
- Journal article