Journal article
Somnogenic, pyrogenic, and hematologic effects of bacterial peptidoglycan
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.258(1), pp.R182-R186
01/01/1990
Handle:
https://hdl.handle.net/2376/113215
PMID: 2105668
Abstract
Bacterial infections and certain muramyl peptides elicit a variety of pathophysiological effects including increases in body temperature and slow-wave sleep. Bacterial cell wall peptidoglycan is composed of muramyl peptides. To investigate the ability of isolated bacterial cell walls to enhance slow-wave sleep, rabbits were injected intravenously with cell walls isolated from Staphylococcus aureus or with soluble peptidoglycan prepared from Neisseria gonorrhoeae. These injections increased slow-wave sleep, electroencephalographic delta-wave amplitudes, and body temperature, reduced rapid-eye-movement sleep, and induced neutrophilia and lymphopenia. The somnogenic and pyrogenic effects of S. aureus cell walls developed within 1 h and persisted throughout the recording period. Injections of N. gonorrhoeae peptidoglycan induced similar effects but of larger magnitude and shorter duration. We conclude that peptidoglycan is a bacterial component that mediates the increased sleep observed during infectious disease.
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Details
- Title
- Somnogenic, pyrogenic, and hematologic effects of bacterial peptidoglycan
- Creators
- L Johannsen - Department of Physiology, University of Tennessee, Memphis38163L. A Toth - Department of Physiology, University of Tennessee, Memphis38163R. S Rosenthal - Department of Physiology, University of Tennessee, Memphis38163M. R Opp - Department of Physiology, University of Tennessee, Memphis38163F Obal - Department of Physiology, University of Tennessee, Memphis38163A. B Cady - Department of Physiology, University of Tennessee, Memphis38163J. M Krueger - Department of Physiology, University of Tennessee, Memphis38163
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.258(1), pp.R182-R186
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900547781901842
- Language
- English
- Resource Type
- Journal article