Journal article
Spatial structure undermines parasite suppression by gene drive cargo
PeerJ (San Francisco, CA), Vol.7, pp.e7921-e7921
10/29/2019
Handle:
https://hdl.handle.net/2376/100263
PMCID: PMC6824332
PMID: 31681512
Abstract
Gene drives may be used in two ways to curtail vectored diseases. Both involve engineering the drive to spread in the vector population. One approach uses the drive to directly depress vector numbers, possibly to extinction. The other approach leaves intact the vector population but suppresses the disease agent during its interaction with the vector. This second application may use a drive engineered to carry a genetic cargo that blocks the disease agent. An advantage of the second application is that it is far less likely to select vector resistance to block the drive, but the disease agent may instead evolve resistance to the inhibitory cargo. However, some gene drives are expected to spread so fast and attain such high coverage in the vector population that, if the disease agent can evolve resistance only gradually, disease eradication may be feasible. Here we use simple models to show that spatial structure in the vector population can greatly facilitate persistence and evolution of resistance by the disease agent. We suggest simple approaches to avoid some types of spatial structure, but others may be intrinsic to the populations being challenged and difficult to overcome.
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Details
- Title
- Spatial structure undermines parasite suppression by gene drive cargo
- Creators
- James J Bull - Department of Biological Sciences, University of Idaho, Moscow, ID, United States of AmericaChristopher H Remien - Department of Mathematics, University of Idaho, Moscow, ID, United States of AmericaRichard Gomulkiewicz - School of Biological Sciences, Washington State University, Pullman, WA, United States of AmericaStephen M Krone - Department of Mathematics, University of Idaho, Moscow, ID, United States of America
- Publication Details
- PeerJ (San Francisco, CA), Vol.7, pp.e7921-e7921
- Academic Unit
- Biological Sciences, School of
- Identifiers
- 99900546543501842
- Language
- English
- Resource Type
- Journal article