Spiropyran-based photochromic polymer nanoparticles with optically switchable luminescence

Ming-Qiang Zhu; Linyong Zhu; Jason J Han; Wuwei Wu; James K Hurst; Alexander D Q Li

doi:10.1021/ja0567642

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Spiropyran-based photochromic polymer nanoparticles with optically switchable luminescence

Journal article

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Spiropyran-based photochromic polymer nanoparticles with optically switchable luminescence

Ming-Qiang Zhu, Linyong Zhu, Jason J Han, Wuwei Wu, James K Hurst and Alexander D Q Li

Journal of the American Chemical Society, Vol.128(13), pp.4303-4309

04/05/2006

DOI: https://doi.org/10.1021/ja0567642

Handle:

https://hdl.handle.net/2376/115836

PMCID: PMC2546359

PMID: 16569006

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Abstract

Microscopy, Electron, Transmission

Humans

Luminescence

Nitro Compounds - chemistry

Fluorescence

Models, Molecular

Spectrometry, Fluorescence

Spectrophotometry, Ultraviolet

Polystyrenes - chemistry

Pyrimidinones - chemistry

Acrylamides - chemistry

Benzopyrans - chemistry

Hydrophobic and Hydrophilic Interactions

Nanostructures - chemistry

Indoles - chemistry

Photochemistry

Polymer nanoparticles of 40-400 nm diameter with spiropyran-merocyanine dyes incorporated into their hydrophobic cavities have been prepared; in contrast to their virtually nonfluorescent character in most environments, the merocyanine forms of the encapsulated dyes are highly fluorescent. Spiro-mero photoisomerization is reversible, allowing the fluorescence to be switched "on" and "off" by alternating UV and visible light. Immobilizing the dye inside hydrophobic pockets of nanoparticles also improves its photostability, rendering it more resistant than the same dyes in solution to fatigue effects arising from photochemical switching. The photophysical characteristics of the encapsulated fluorophores differ dramatically from those of the same species in solution, making nanoparticle-protected hydrophobic fluorophores attractive materials for potential applications such as optical data storage and switching and biological fluorescent labeling. To evaluate the potential for biological tagging, these optically addressable nanoparticles have been delivered into living cells and imaged with a liquid nitrogen-cooled CCD.

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Title: Spiropyran-based photochromic polymer nanoparticles with optically switchable luminescence
Creators: Ming-Qiang Zhu - Department of Chemistry, Washington State University, Pullman, 99164, USA
Linyong Zhu
Jason J Han
Wuwei Wu
James K Hurst
Alexander D Q Li
Publication Details: Journal of the American Chemical Society, Vol.128(13), pp.4303-4309
Academic Unit: Chemistry, Department of
Publisher: United States
Grant note: GM065306 / NIGMS NIH HHS R01 GM065306-04 / NIGMS NIH HHS R01 GM065306-02 / NIGMS NIH HHS R01 GM065306 / NIGMS NIH HHS R01 GM065306-01A1 / NIGMS NIH HHS R01 GM065306-03 / NIGMS NIH HHS
Identifiers: 99900547533701842
Language: English
Resource Type: Journal article