Journal article
Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes
Brain research, Vol.973(2), pp.214-222
05/30/2003
Handle:
https://hdl.handle.net/2376/101492
PMID: 12738065
Abstract
Nitric oxide (NO) affects almost every physiological process, including the regulation of sleep. There is strong evidence that NO plays an important role in rapid eye movement sleep (REMS) regulation. To further investigate the role of NO in sleep, we characterized spontaneous sleep in mice with targeted disruptions (knockout; KO) in the neuronal nitric oxide synthase (nNOS) or inducible (i)NOS genes. REMS in nNOS KO mice was substantially lower than that of their control mice. In contrast, the iNOS KO mice had significantly more REMS than their controls. Inducible NOS KO mice also had less non-REMS (NREMS) during the dark period. Results suggest that nNOS and iNOS play opposite roles in REMS regulation.
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Details
- Title
- Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes
- Creators
- Lichao Chen - Department of VCAPP, Washington State University, Pullman, WA 99164-6520, USAJeannine A MajdeJames M Krueger
- Publication Details
- Brain research, Vol.973(2), pp.214-222
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Netherlands
- Grant note
- HD 36520 / NICHD NIH HHS NS 25378 / NINDS NIH HHS
- Identifiers
- 99900546794201842
- Language
- English
- Resource Type
- Journal article