Journal article
State-Dependent Modulation of Visual Evoked Potentials in a Rodent Genetic Model of Electroencephalographic Instability
Frontiers in systems neuroscience, Vol.12, pp.36-36
08/15/2018
Handle:
https://hdl.handle.net/2376/106691
PMCID: PMC6104170
PMID: 30158860
Abstract
Despite normal sleep timing and duration,
Egr3
-deficient (
Egr3
−/−
) mice exhibit electroencephalographic (EEG) characteristics of reduced arousal, including elevated slow wave (1–4 Hz) activity during wakefulness. Here we show that these mice exhibit state-dependent instability in the EEG. Intermittent surges in EEG power were found in
Egr3
−/−
mice during wakefulness and rapid eye movement sleep, most prominently in the beta (15–35 Hz) range compared to wild type (
Egr3
+/+
) mice. Such surges did not coincide with sleep onset, as the surges were not associated with cessation of electromyographic tone. Cortical processing of sensory information by visual evoked responses (VEP) were found to vary as a function of vigilance state, being of higher magnitude during slow wave sleep (SWS) than wakefulness and rapid eye movement sleep. VEP responses were significantly larger during quiet wakefulness than active wakefulness, in both
Egr3
−/−
mice and
Egr3
+/+
mice. EEG synchronization in the beta range, previously linked to the accumulation of sleep need over time, predicted VEP magnitude.
Egr3
−/−
mice not only displayed elevated beta activity, but in quiet wake, this elevated beta activity coincides with an elevated evoked response similar to that of animals in SWS. These data confirm that (a) VEPs vary as a function of vigilance state, and (b) beta activity in the EEG is a predictor of state-dependent modulation of visual information processing. The phenotype of
Egr3
−/−
mice indicates that
Egr3
is a genetic regulator of these phenomena.
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Details
- Title
- State-Dependent Modulation of Visual Evoked Potentials in a Rodent Genetic Model of Electroencephalographic Instability
- Creators
- Janne Grønli - Department of Biological and Medical Psychology, University of BergenMichelle A Schmidt - Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State UniversityJonathan P Wisor - Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University
- Publication Details
- Frontiers in systems neuroscience, Vol.12, pp.36-36
- Academic Unit
- Biomedical Sciences, Department of
- Publisher
- Frontiers Media S.A
- Grant note
- R21DA037708 / National Institutes of Health
- Identifiers
- 99900546864701842
- Language
- English
- Resource Type
- Journal article