Journal article
Stimulation of coho salmon growth by insulin-like growth factor I
General and comparative endocrinology, Vol.86(3), pp.398-406
1992
Handle:
https://hdl.handle.net/2376/104023
PMID: 1398004
Abstract
The effect of insulin-like growth factor I on growth rate of coho salmon (
Oncorhynchus kisutch) was examined. Juvenile coho salmon received implants of osmotic minipumps containing recombinant bovine insulin-like growth factor I (rbIGF-I) or saline for a period of 3 to 4 weeks. High doses of rbIGF-I (>0.13 μg · g
−1 · d
−1) resulted in hypoglycemia and death. In 2-year-old coho salmon, 0.09 μg · g
−1 · d
−1 rbIGF-I administered for 25 days doubled linear growth rate and increased growth rate in weight by 40%. In rapidly growing, 1-year-old coho salmon, growth rate was not altered by rbIGF-I at 0.01 or 0.05 μg · g
−1 · d
−1 for 31 days. In ration-limited fish exhibiting slow growth in the control group, rbIGF-I (0.02 to 0.12 μg · g
−1 · d
−1) increased linear growth rate by up to threefold and growth rate in weight by up to fourfold. The results indicate that exogenous treatment with mammalian IGF-I can stimulate coho salmon growth under some conditions, and that endogenous IGF-I may be an important factor in regulating growth of teleosts.
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Details
- Title
- Stimulation of coho salmon growth by insulin-like growth factor I
- Creators
- Stephen D McCormick - Department of Integrative Biology, Cancer Research Laboratory, University of California, Berkeley, California 94720 USAKevin M Kelley - Department of Integrative Biology, Cancer Research Laboratory, University of California, Berkeley, California 94720 USAGraham Young - Department of Integrative Biology, Cancer Research Laboratory, University of California, Berkeley, California 94720 USARichard S Nishioka - Department of Integrative Biology, Cancer Research Laboratory, University of California, Berkeley, California 94720 USAHoward A Bern - Department of Integrative Biology, Cancer Research Laboratory, University of California, Berkeley, California 94720 USA
- Publication Details
- General and comparative endocrinology, Vol.86(3), pp.398-406
- Academic Unit
- UNKNOWN
- Publisher
- Elsevier Inc
- Identifiers
- 99900546733101842
- Language
- English
- Resource Type
- Journal article