Journal article
Strain Diversity in Major Surface Protein 2 Expression during Tick Transmission of Anaplasma marginale
Infection and immunity, Vol.68(5), pp.3023-3027
Note
05/2000
Handle:
https://hdl.handle.net/2376/113114
PMCID: PMC97523
PMID: 10769008
Abstract
Specific major surface protein 2 (MSP2) variants are expressed by
Anaplasma marginale
within the tick salivary gland and, following transmission, are expressed during acute rickettsemia. In previous work, we have shown that a restricted pattern of MSP2 variants is expressed in the salivary glands of
Dermacentor andersoni
ticks infected with the South Idaho strain of
A. marginale
. Now we demonstrate that the identical restriction does not apply to two other strains of
A. marginale
, and that different variants are also expressed when the same strain is transmitted by different
Dermacentor
spp. This indicates that antigenic diversity among strains is maintained in tick transmission and may be a significant constraint to MSP2 vaccine development.
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Details
- Title
- Strain Diversity in Major Surface Protein 2 Expression during Tick Transmission of Anaplasma marginale
- Creators
- Fred R Rurangirwa - Program in Vector-Borne Diseases, Washington State University, Pullman, Washington, 99164-7040David Stiller - Program in Vector-Borne Diseases, Washington State University, Pullman, Washington, 99164-7040Guy H Palmer - Program in Vector-Borne Diseases, Washington State University, Pullman, Washington, 99164-7040
- Publication Details
- Infection and immunity, Vol.68(5), pp.3023-3027
- Academic Unit
- Paul G. Allen School for Global Animal Health
- Series
- Note
- Publisher
- American Society for Microbiology
- Identifiers
- 99900547601301842
- Language
- English
- Resource Type
- Journal article