Journal article
Strain-dependent differences in responsiveness of mice to nitrous oxide (N 2O) antinociception
Brain research, Vol.614(1), pp.52-56
1993
Handle:
https://hdl.handle.net/2376/116563
PMID: 8348330
Abstract
N
2O antinociception was assessed in eight inbred and two outbred mouse strains. Results indicated the following order of responsiveness among the 10 strains: A/J (most sensitive), C57BL/6ByJ, C57BL/6J, BALB/cByJ, C3H/HeJ, Swiss-Webster, CXBK/ByJ, ICR, CBA/J and DBA/2J (least sensitive). These results demonstrate significant strain-dependent differences in antinociceptive responsiveness to N
2O. The weak antinociceptive response to N
2O in the DBA/2J strain, which is sensitive to morphine and U-50,488H, indicates some underlying neurobiological difference in the DBA/2J mouse that imparts resistance to N
2O. The responsiveness of CXBK/ByJ mice to N
2O indicates that μ-opioid receptors may not play an important role in N
2O antinociception in mice.
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Details
- Title
- Strain-dependent differences in responsiveness of mice to nitrous oxide (N 2O) antinociception
- Creators
- Raymond M Quock - Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107 - 1897 USAJanet L Mueller - Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107 - 1897 USALinda K Vaughn - Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107 - 1897 USA
- Publication Details
- Brain research, Vol.614(1), pp.52-56
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547776601842
- Language
- English
- Resource Type
- Journal article