Strain variation of Babesia bovis merozoite surface-exposed epitopes

G H Palmer; T F McElwain; L E Perryman; W C Davis; D R Reduker; D P Jasmer; V Shkap; E Pipano; W L Goff; T C McGuire

doi:10.1128/IAI.59.9.3340-3342.1991

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Strain variation of Babesia bovis merozoite surface-exposed epitopes

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Strain variation of Babesia bovis merozoite surface-exposed epitopes

G H Palmer, T F McElwain, L E Perryman, W C Davis, D R Reduker, D P Jasmer, V Shkap, E Pipano, W L Goff and T C McGuire

Infection and immunity, Vol.59(9), pp.3340-3342

09/1991

DOI: https://doi.org/10.1128/IAI.59.9.3340-3342.1991

Handle:

https://hdl.handle.net/2376/116183

PMCID: PMC258180

PMID: 1715329

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https://doi.org/10.1128/IAI.59.9.3340-3342.1991View

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Abstract

Babesia bovis merozoites are exposed to antibodies during the extraerythrocytic phase, and surface polypeptides bearing exposed epitopes are possible immunogens. Monoclonal antibodies reactive with the merozoite surface bind either immunodominant epitopes expressed diffusely on the merozoite surface or, alternatively, epitopes expressed in a polar pattern. Epitopes expressed diffusely on the immunodominant 42- and 44-kDa merozoite polypeptides were not conserved among strains from geographically diverse regions. In contrast, epitopes expressed in a polar pattern on the merozoite surface were conserved among nine strains and clones. Identification of variables and conserved epitopes provides a basis for defining antigenic variation and cross-protective immunity.

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Title: Strain variation of Babesia bovis merozoite surface-exposed epitopes
Creators: G H Palmer - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman
T F McElwain - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman
L E Perryman - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman
W C Davis - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman
D R Reduker - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman
D P Jasmer - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman
V Shkap - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman
E Pipano - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman
W L Goff - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman
T C McGuire - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman
Publication Details: Infection and immunity, Vol.59(9), pp.3340-3342
Academic Unit: Veterinary Microbiology and Pathology, Department of; Paul G. Allen School for Global Animal Health
Identifiers: 99900548260901842
Language: English
Resource Type: Journal article