Journal article
Study of the distribution of actinides in human tissues using synchrotron radiation micro X-ray fluorescence spectrometry
Analytical and bioanalytical chemistry, Vol.407(6), pp.1559-1566
02/2015
Handle:
https://hdl.handle.net/2376/116388
PMID: 25542585
Abstract
This study aims at evaluating the capabilities of synchrotron radiation micro X-ray fluorescence spectrometry (SR micro-XRF) for qualitative and semi-quantitative elemental mapping of the distribution of actinides in human tissues originating from individuals with documented occupational exposure. The investigated lymph node tissues were provided by the United States Transuranium and Uranium Registries (USTUR) and were analyzed following appropriate sample pre-treatment. Semi-quantitative results were obtained via calibration by external standards and demonstrated that the uranium concentration level in the detected actinide hot spots reaches more than 100 μg/g. For the plutonium hot spots, concentration levels up to 31 μg/g were found. As illustrated by this case study on these unique samples, SR micro-XRF has a high potential for this type of elemental bio-imaging owing to its high sensitivity, high spatial resolution, and non-destructive character.ᅟ
Graphical Abstract
SR micro-XRF study of the distribution of actinitides in human tissues. Left Location of the U-contaminated tissue sample in the human body. Middle U distribution derived from the high resolution SR micro-XRF scan on the tissue sample, indication of five U hot spots. Right Detail of the point measurement spectrum of U hot spot 3, intense U-Lα fluorescence peak located at 13.6 keV.
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Details
- Title
- Study of the distribution of actinides in human tissues using synchrotron radiation micro X-ray fluorescence spectrometry
- Creators
- Eva Vergucht - Department of Analytical Chemistry Ghent University Krijgslaan 281 (S12) 9000 Ghent BelgiumBjörn De Samber - Department of Analytical Chemistry Ghent University Krijgslaan 281 (S12) 9000 Ghent BelgiumAndrei Izmer - Department of Analytical Chemistry Ghent University Krijgslaan 281 (S12) 9000 Ghent BelgiumBart Vekemans - Department of Analytical Chemistry Ghent University Krijgslaan 281 (S12) 9000 Ghent BelgiumKaren Appel - European XFEL Albert-Einstein-Ring 19 22761 Hamburg GermanySergei Tolmachev - United States Transuranium and Uranium Registries, College of Pharmacy Washington State University 1845 Terminal Dr, Ste 201 Richland WA 99354 USALaszlo Vincze - Department of Analytical Chemistry Ghent University Krijgslaan 281 (S12) 9000 Ghent BelgiumFrank Vanhaecke - Department of Analytical Chemistry Ghent University Krijgslaan 281 (S12) 9000 Ghent Belgium
- Publication Details
- Analytical and bioanalytical chemistry, Vol.407(6), pp.1559-1566
- Academic Unit
- Pharmaceutical Sciences, Department of
- Publisher
- Springer Berlin Heidelberg; Berlin/Heidelberg
- Identifiers
- 99900548142401842
- Language
- English
- Resource Type
- Journal article