Journal article
Suspected ciliary dysfunction in Chinese Shar Pei pups with pneumonia
American journal of veterinary research, Vol.51(3), pp.439-446
03/1990
Handle:
https://hdl.handle.net/2376/104172
PMID: 2316922
Abstract
Chronic pneumonia was investigated in a litter of young Chinese Shar Pei in which 4 of 6 dogs were affected. Serum immunoglobulin concentrations (IgA, IgG, IgM) determined by radial immunodiffusion varied over time, but were not consistently lower in affected dogs, compared with control dogs. Two dogs that died had hydrocephalus and lymphoid depletion, in addition to severe broncho-pneumonia. Evaluation of ciliary ultrastructure in 2 affected dogs revealed random orientation of adjacent respiratory tract or oviductal cilia and a greater number of microtubular disarrangements, compared with control dogs. In vivo tracheal mucociliary clearance of 99mtechnetium macroaggregated albumin was absent in 1 dog examined. The ciliary abnormalities were suspected to have resulted in an inefficient mucociliary transport system predisposing to the development of pneumonia. Further evaluation of 1 Chinese Shar Pei revealed lymphocyte mitogenesis results that were not consistently less than those of a control dog, normal total hemolytic complement values, and normal blood neutrophil chemotaxis.
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Details
- Title
- Suspected ciliary dysfunction in Chinese Shar Pei pups with pneumonia
- Creators
- C R Dhein - Department of Veterinary Clinical Medicine and Surgery, Washington State University, Pullman 99164D J PrieurM W RiggsK A PotterP R Widders
- Publication Details
- American journal of veterinary research, Vol.51(3), pp.439-446
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- United States
- Grant note
- RR00515 / NCRR NIH HHS
- Identifiers
- 99900546760901842
- Language
- English
- Resource Type
- Journal article